What's this test for?

This test is ideal if you have a personal or family history of colon, endometrial, or other related cancers, especially if they occurred at a younger age than typical. It looks for inherited genetic changes that can raise your lifetime risk of developing these cancers, which is important information if multiple relatives have had cancer or if a family member has already tested positive for a PMS2 mutation. Knowing your genetic status can help guide decisions about cancer screening frequency and timing.

What's included in this test?

This test analyzes the PMS2 gene using two complementary methods: full sequencing to catch small spelling changes in the gene's code, and deletion/duplication analysis to catch larger missing or extra chunks of genetic material. Using both methods together matters because PMS2 mutations often come from large deletions that sequencing alone would miss, giving you a more complete picture of your risk.

What happens after I get my results?

Your results will appear securely in your account, with a clear explanation of what a positive, negative, or uncertain finding means. If a mutation is found, next steps typically include starting earlier or more frequent cancer screenings and sharing the information with blood relatives who may also be at risk. You can download the full lab report from your account at any time, and since this is a one-time genetic result, there's no need for routine retesting, though you can track any related follow-up test results over time using the trends feature.

How can I naturally support colon health while managing genetic risk?

While no lifestyle change can undo an inherited genetic mutation, you can support your colon health by eating more fiber-rich foods, limiting red and processed meats, staying physically active, and avoiding smoking and heavy alcohol use. Maintaining a healthy weight also helps lower general colorectal cancer risk. These habits work best alongside, not instead of, appropriate cancer screening for your risk level.

When will I get my results?

Results are typically ready within about 7 days after your sample is processed at the lab. You'll receive a notification once your report is available, and you can log into your account to view the detailed findings at that time.

Who should consider this test?

This test is a good fit for people with a family history of colon, endometrial, ovarian, or related cancers, particularly if those cancers were diagnosed before age 50. It's also useful if a close relative has already been found to carry a PMS2 mutation, or if your family pattern of cancer suggests Lynch syndrome may be present. People of any age who want to understand their inherited cancer risk before starting a family may also consider this test.

What symptoms indicate I may need this test?

Lynch syndrome itself doesn't cause symptoms on its own, since it's an inherited risk factor rather than a disease. Instead, the signals to watch for are patterns in your family's health history, like several relatives with colon or endometrial cancer, cancer diagnosed at a young age, or multiple different cancers in the same person. If any of these describe your family, this test can help clarify whether a PMS2 mutation is contributing to that pattern.

What is Lynch syndrome and why does it matter?

Lynch syndrome is an inherited condition where the body's DNA repair system doesn't work as well as it should, making it easier for cells to develop cancer-causing errors over time. PMS2 is one of four genes involved in this repair system, and mutations here account for a smaller share of Lynch syndrome cases than the other genes. Knowing you carry a PMS2 mutation matters because it means starting cancer screenings like colonoscopies earlier and more often can catch problems before they become serious.

What does a positive result mean for my family?

A positive result means you carry a PMS2 mutation that raises your cancer risk, and it also means your siblings, parents, and children each have roughly a 50% chance of carrying the same mutation. Sharing your results with close relatives gives them the option to get tested too, so they can also take proactive steps with their own screening schedule. This kind of result is about managing risk early, not a diagnosis of cancer itself.

What should I do if my results show a mutation?

If your report shows a PMS2 mutation, the most useful next step is starting more frequent cancer screening, such as earlier and more regular colonoscopies, as recommended for people with Lynch syndrome. It's also worth having close relatives consider testing, since they may share the same inherited change. If you experience any concerning symptoms like unexplained bleeding, persistent digestive changes, or unexplained weight loss, seek medical care promptly rather than waiting for a routine screening.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

PMS2 Lynch Syndrome Test - Hereditary Cancer Risk

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]

Lynch Syndrome PMS2 Gene Test for Colon Cancer Risk

Lynch Syndrome, PMS2 Sequencing and Deletion/Duplication

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

What's this test for?

What's included in this test?

What happens after I get my results?

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Lynch Syndrome PMS2 Gene Test for Colon Cancer Risk

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

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