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Immune system test for people monitoring inflammatory conditions and immune response

Blood Test for Immune System Activity & Inflammation

Interleukin-2 Receptor Alpha Chain (IL-2Ra/CD25), Soluble

Google
3,138 reviews
  • Checks immune system activity levels.
  • Measures body's inflammation response.
  • Detects immune-related health conditions.
First results as soon as overnight*

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you're being evaluated for immune system disorders, unexplained inflammation, or certain types of cancers like lymphoma or leukemia. It measures a marker called soluble IL-2 receptor that becomes elevated when your immune system is overactive or abnormal. Many people use this test when monitoring known autoimmune conditions, tracking treatment response, or when their doctor suspects an immune-related disorder.

How should I prepare for this test?

No biotin: 48 hours

You should avoid taking biotin supplements for at least 48 hours before your blood draw. Biotin can interfere with certain laboratory tests and may affect the accuracy of your results. Otherwise, no special preparation like fasting is typically required for this test.

What's included in this test?

Interleukin-2 Receptor Alpha Chain (IL-2Ra/CD25), Soluble

This test measures the level of soluble IL-2 receptor alpha chain (CD25) in your blood, which is a protein released when immune cells become activated. Elevated levels can indicate various conditions including autoimmune disorders like sarcoidosis, inflammatory conditions, lymphoproliferative disorders, and certain cancers. This single biomarker provides valuable information about immune system activity and is often used to monitor disease progression or treatment effectiveness.

What happens after I get my results?
You'll receive detailed doctor notes in simple language explaining what your IL-2 receptor level means for your immune system health. These notes include personalized recommendations about lifestyle factors that support immune balance, when to follow up with a specialist like an immunologist or oncologist, and whether additional testing may be helpful. You'll also get the standard lab report and can track your levels over time using our trends feature, which is especially useful if you're monitoring a chronic condition or treatment response.
Who should consider this test?
This test is particularly useful for people being evaluated for lymphoma, leukemia, or autoimmune conditions like sarcoidosis or rheumatoid arthritis. It's also valuable for those already diagnosed with immune-related disorders who need to monitor disease activity or treatment response. Your doctor may order this test if you have unexplained swollen lymph nodes, persistent inflammation, or symptoms suggesting immune system dysfunction.
What symptoms indicate I may need this test?
Symptoms that might prompt this test include unexplained swollen lymph nodes, persistent fevers, night sweats, unexplained weight loss, or chronic fatigue. You might also need this test if you have joint pain and inflammation, breathing problems related to immune conditions, or if you're experiencing symptoms of autoimmune disease. It's often ordered as part of an investigation when other blood tests show signs of immune system abnormalities.
What is soluble IL-2 receptor and why does it matter?
Soluble IL-2 receptor (sIL-2R) is a protein that gets released into your bloodstream when certain immune cells called T-cells become activated. It's essentially a marker of immune system activity. When your immune system is working harder than normal due to infection, inflammation, autoimmune disease, or certain cancers, this marker increases. Doctors use it to assess disease severity, predict outcomes, and monitor how well treatments are working.
What does high soluble IL-2 receptor mean?
Elevated levels of soluble IL-2 receptor indicate increased immune system activation. This can happen with various conditions including lymphomas (especially Hodgkin's disease and non-Hodgkin's lymphoma), leukemias, autoimmune disorders like sarcoidosis or rheumatoid arthritis, certain infections, and inflammatory conditions. Higher levels often correlate with more active or severe disease and can help your doctor determine the best treatment approach.
How can I naturally support my immune system health?
Supporting healthy immune function involves eating a balanced diet rich in fruits, vegetables, and whole foods that provide essential vitamins and minerals. Getting adequate sleep (7-9 hours nightly), managing stress through meditation or relaxation techniques, and staying physically active all help regulate immune function. Avoiding smoking, limiting alcohol, and staying hydrated also support immune balance. However, if you have an immune disorder, always follow your doctor's treatment plan.
How often should I retest soluble IL-2 receptor levels?
Retesting frequency depends on your specific situation. If you're being monitored for active disease like lymphoma or an autoimmune condition, your doctor may order tests every few weeks to months to track disease activity and treatment response. For baseline monitoring or follow-up after treatment, testing every 3-6 months may be appropriate. Your healthcare provider will determine the best schedule based on your diagnosis and clinical situation.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Soluble IL-2 Receptor (sIL-2R) 825 U/mL
Demo results
Normal < 650 Elevated ≥ 650
825 U/mL

What this means

Your soluble IL-2 receptor level is elevated above the normal range, which indicates increased immune system activation. This may be related to inflammation, an autoimmune condition, or other immune-related processes that should be discussed with your healthcare provider for proper evaluation and monitoring.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Blood Test for Immune System Activity & Inflammation

Google
3,138 reviews
  • Checks immune system activity levels.
  • Measures body's inflammation response.
  • Detects immune-related health conditions.

1,000,000+ blood tests later, here's what our customers say

Google reviews 3138 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.