What's this test for?

This test is ideal if you're at higher risk for anal HPV-related changes, such as if you have a history of abnormal anal Pap results, receptive anal intercourse, or a weakened immune system. It checks for high-risk HPV activity in rectal cells that can lead to precancerous changes called anal dysplasia. It's typically used alongside a cytology (Pap-type) test for a fuller picture of anal cell health.

What happens after I get my results?

Your results will show up in your online account, with each value explained so you know what's normal and what's not. If your result is positive, a common next step is closer monitoring or a follow-up procedure to check the anal tissue more closely, while a negative result usually means routine rescreening on a schedule based on your risk factors. You can download the full lab report from your account anytime, and the trends feature lets you track results over time if you retest in the future. If you notice symptoms like rectal bleeding, pain, or unusual growths, seek medical care promptly.

Who should consider this test?

This test is a good fit for people with a history of abnormal anal cytology, receptive anal sex, HIV or other immune-suppressing conditions, or a prior HPV diagnosis. It's also useful for anyone whose recent anal Pap test came back unclear or abnormal. If you fall into a higher-risk group for anal cancer, this test helps catch changes early.

What symptoms indicate I may need this test?

Most people with HPV-related cell changes have no symptoms at all, which is why screening matters. Some signs that could prompt testing include rectal bleeding, itching, pain, or a lump near the anus. Even without symptoms, if you're in a higher-risk group, testing is worth considering as a proactive step.

What is HPV and why does it matter?

HPV (human papillomavirus) is a very common virus spread through skin-to-skin contact, and certain high-risk strains can cause cell changes that sometimes turn into cancer over time. This test looks for the genetic activity (mRNA) of the E6 and E7 proteins from high-risk HPV strains, which are the ones most linked to abnormal cell growth. Catching this activity early means changes can be monitored or treated before they progress.

How can I naturally support my immune system against HPV?

A strong immune system helps your body clear HPV infections on its own, so basics like getting enough sleep, eating a balanced diet, and managing stress genuinely help. Quitting smoking is one of the most impactful steps, since smoking weakens the immune response and is linked to slower HPV clearance. Staying up to date on the HPV vaccine, if eligible, and limiting new exposures can also lower ongoing risk.

What does a positive result mean?

A positive result means high-risk HPV genetic activity was found in the rectal cells tested, which suggests a higher chance of developing abnormal cell changes. It doesn't mean cancer is present — it's a signal to look closer, often with a follow-up procedure that examines the tissue directly. Many HPV infections are cleared by the body over time, especially in people with healthy immune systems.

How often should I retest?

Retesting frequency depends on your risk factors and your prior results, but people at higher risk are often rescreened every 1-3 years. If a previous result was abnormal, closer follow-up on a shorter timeline is common. Tracking your results over time in your account can help you and any follow-up specialists see patterns.

What should I do if my results are abnormal?

If your result comes back abnormal, the recommended next step is usually a closer examination of the anal tissue to check for precancerous changes. In the meantime, avoiding smoking, practicing safer sex, and keeping up with recommended follow-up testing are all practical steps you can take. Don't panic — an abnormal result is a signal to monitor closely, not a diagnosis of cancer.

What causes an abnormal or positive result?

A positive result happens when high-risk HPV strains are actively infecting the rectal cells and producing E6/E7 proteins, which can interfere with normal cell growth control. Risk factors that make this more likely include a weakened immune system, smoking, multiple sexual partners, and receptive anal intercourse without protection. Reducing these risk factors over time can lower your chances of persistent infection.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

HPV mRNA E6/E7 Rectal Test - Anal Dysplasia Screening

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]

HPV mRNA E6/E7 Rectal Test for Anal Dysplasia Screening