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FISH test for BCR/ABL1 translocation used in leukemia diagnosis and evaluation

BCR/ABL1 FISH Test for Leukemia (Philadelphia Chromosome)

FISH, CML/ALL, bcr/abl, Translocation 9,22

  • Detect leukemia-linked genetic changes early
  • Screen for Philadelphia chromosome markers
  • Assess blood cancer diagnosis clues
$1967
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

What's this test for?

This test is ideal if you're being evaluated for a possible blood cancer diagnosis, particularly chronic myelogenous leukemia (CML) or acute lymphocytic leukemia (ALL). It helps if your blood counts or bone marrow findings have raised concerns and more specific genetic information is needed to confirm what's going on. This test looks for a specific genetic change called the Philadelphia chromosome that is linked to these conditions.

What's included in this test?

This test uses a specialized lab technique called FISH to look closely at your chromosomes for a specific rearrangement between two genes. This rearrangement matters because it creates an abnormal, shortened chromosome that is strongly linked to certain leukemias, so finding it (or ruling it out) gives important diagnostic information.

What happens after I get my results?

Your results will be available in your account, with an explanation of what a positive or negative finding means. Because this test looks for a specific genetic marker tied to serious blood conditions, any positive or unclear result should be followed up quickly with further specialized testing to determine next steps. The standard lab report is downloadable from your account at any time, and if you retest in the future, you can track and compare results over time using the trends feature.

Who should consider this test?
This test is generally considered when blood work or bone marrow findings already suggest a possible leukemia and more specific confirmation is needed. It's also useful for people with a leukemia diagnosis where standard chromosome analysis hasn't been able to detect the underlying genetic change. People with a family history of blood cancers who are undergoing broader diagnostic workups may also have this test recommended as part of that evaluation.
What symptoms indicate I may need this test?
Symptoms like unusual fatigue, easy bruising or bleeding, unexplained weight loss, night sweats, frequent infections, or an enlarged spleen can sometimes point toward a blood cancer like CML or ALL. These symptoms alone don't confirm anything, but combined with abnormal blood counts, they're often the reason this type of genetic testing gets ordered. If you're experiencing several of these symptoms together, it's worth discussing broader blood cancer testing as a next step.
What is the Philadelphia chromosome and why does it matter?
The Philadelphia chromosome is an abnormally short chromosome 22 that forms when pieces of chromosome 9 and chromosome 22 swap places and fuse two genes together in the wrong way. This fusion creates an abnormal protein that can drive uncontrolled growth of blood cells, which is why it's so closely tied to CML and some cases of ALL. Detecting it helps confirm a diagnosis and can guide the type of treatment that's likely to work best.
What does a positive result mean?
A positive result means the specific gene rearrangement linked to the Philadelphia chromosome was found in your sample, which supports a diagnosis of CML or Philadelphia-positive ALL depending on your clinical picture. This is a significant finding and typically means additional testing and prompt follow-up care are needed right away. Because this particular test isn't designed to measure disease levels over time, a more sensitive method like PCR is usually used for ongoing monitoring.
What does a negative result mean?
A negative result means this specific gene rearrangement wasn't detected in your sample, which makes CML or Philadelphia-positive ALL less likely but doesn't completely rule out all types of leukemia. Some rare, complex chromosome rearrangements can occasionally be missed, so if symptoms or other blood findings still raise concern, further testing may still be appropriate. Discuss any persistent symptoms with the context of your full blood work picture.
How often should I retest?
This test isn't typically used for routine monitoring since it isn't designed to measure changes in disease activity over time. If you've already been diagnosed with a Philadelphia-positive condition, ongoing monitoring is usually done with a more sensitive method rather than repeating this exact test. Retesting with this specific FISH panel would generally only make sense if there's a new diagnostic question or unclear findings on other tests.
What should I do if my results are abnormal?
If your result comes back positive, treat it as time-sensitive and seek prompt follow-up testing and care, since this points toward a possible serious blood condition. Bring your full lab report, since it explains exactly what was detected and how. In the meantime, try to keep track of any symptoms you're noticing, such as fatigue or unusual bruising, so you have clear information ready for next steps.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

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Demo results
BCR/ABL1 Translocation (Philadelphia Chromosome) Negative
Demo results
Negative Positive
Negative

What this means

A negative result means the specific BCR/ABL1 gene rearrangement linked to the Philadelphia chromosome was not detected in your sample. This makes chronic myelogenous leukemia (CML) or Philadelphia-positive acute lymphocytic leukemia (ALL) less likely, though it doesn't rule out all forms of leukemia. Your full blood work and symptoms should still be considered together.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
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Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

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BCR/ABL1 FISH Test for Leukemia (Philadelphia Chromosome)

  • Detect leukemia-linked genetic changes early
  • Screen for Philadelphia chromosome markers
  • Assess blood cancer diagnosis clues
$1967
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.