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DAT blood test detecting immune-mediated red cell destruction and hemolytic anemia

Direct Antiglobulin (Coombs) Test for Hemolytic Anemia

Direct Antiglobulin Test (DAT) with Reflex to Anti C3 and Anti IgG

  • Detect immune attacks on red cells
  • Screen for transfusion reaction causes
  • Check unexplained fatigue and paleness
$74
First results as soon as overnight*

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

Prescription & all lab fees included

Go directly to the lab, no extra fees

Doctor's guidance included

Easy to understand results

Fast & convenient

Lab visit as quick as 10 mins in & out

All results normal? Get your money back. First-time customers only. File a support ticket titled “Money Back Guarantee” with your order number within 15 days of receiving your results. STD, Sickle Cell, and gift orders aren’t eligible. Full terms apply. guarantee
No questions asked refunds
LegitScript certified

What's this test for?

This test is ideal if you're experiencing unexplained fatigue, pale skin, yellowing of the eyes or skin, or dark urine, which can be signs your body is destroying red blood cells too quickly. It's also useful if you've recently had a blood transfusion and are having a reaction, or if you're on a medication known to sometimes trigger red blood cell problems. The test checks whether your immune system is mistakenly attacking your own red blood cells.

What happens after I get my results?

Your results will show up in your account with a clear explanation of what a positive or negative result means. A positive result may lead to reflex testing for anti-C3 and anti-IgG, which helps pinpoint the type of immune reaction happening, and the report explains those follow-up values too. If your result is positive, it's worth noting any new medications, recent transfusions, or symptoms like fatigue and dizziness, and seeking prompt medical care if symptoms are severe. You can download the full lab report anytime and track any repeat testing over time using the trends feature.

Who should consider this test?

Anyone with symptoms of anemia like fatigue, paleness, or yellowing skin should consider this test, especially if there's no clear explanation like blood loss or diet. It's also recommended for people who had a transfusion and developed a fever, chills, or dark urine afterward. People taking certain medications linked to immune reactions against red blood cells may also want to check this.

What symptoms indicate I may need this test?
Common signs include unusual tiredness, weakness, shortness of breath, pale or yellow-tinged skin, and dark or tea-colored urine. Some people also notice a rapid heartbeat or feel dizzy when standing up. If these symptoms appeared after starting a new medication or getting a blood transfusion, that's a strong reason to get tested.
When will I get my results?
Results are typically ready within about 7 days of your sample being tested. If the initial test comes back positive, the reflex testing for anti-C3 and anti-IgG is done automatically on the same sample, which may add a small amount of time. You'll get a notification as soon as your results are posted to your account.
What does a positive result mean?
A positive result means your immune system has coated your red blood cells with antibodies or complement proteins, which can lead to the cells being destroyed faster than your body can replace them. This can happen due to autoimmune conditions, a reaction to a blood transfusion, or certain medications. The reflex panel showing anti-C3 or anti-IgG helps clarify which type of immune reaction is involved, which matters for figuring out next steps.
What causes a positive DAT result?
The most common causes are autoimmune hemolytic anemia, where the body mistakenly attacks its own red blood cells, transfusion reactions, and certain drugs like some antibiotics or blood pressure medications. Some infections and underlying conditions like lupus can also trigger a positive result. Reviewing recent medications and health history often helps narrow down the cause.
How often should I retest?
If you're being monitored for an ongoing condition or after starting a new medication, retesting every few months or as symptoms change can help track whether the immune reaction is improving. If your first test was negative but symptoms persist, retesting after any new triggers like transfusions or medication changes makes sense. Using the trends feature lets you see how your results change over time.
What should I do if my results are abnormal?
If your result is positive, pay attention to symptoms like worsening fatigue, rapid heart rate, or dark urine, since these can signal your body isn't keeping up with red blood cell loss. Keep a record of any new medications or recent transfusions to help identify the trigger. Severe symptoms like chest pain, severe shortness of breath, or fainting call for immediate emergency care.
What is autoimmune hemolytic anemia and why does it matter?
Autoimmune hemolytic anemia happens when your immune system mistakenly targets and destroys your own red blood cells, leading to anemia. It matters because red blood cells carry oxygen throughout your body, so losing them faster than they're replaced can cause serious fatigue, heart strain, and other complications if untreated. Catching it early through testing like the DAT helps identify the problem before it becomes severe.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Get lab order in minutes, results come overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Direct Antiglobulin Test (DAT) Negative
Demo results
Negative (Normal) Positive (Abnormal)
Negative

What this means

A negative result means your red blood cells are not coated with antibodies or complement proteins, so there's no evidence of immune-mediated red cell destruction at this time. This is the expected, healthy result for most people.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More advanced tests may take longer due to complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

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Direct Antiglobulin (Coombs) Test for Hemolytic Anemia

  • Detect immune attacks on red cells
  • Screen for transfusion reaction causes
  • Check unexplained fatigue and paleness
$74
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.
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For informational purposes only. Not medical advice.