What's this test for?

This test is ideal if you're about to start chemotherapy with 5-fluorouracil (5-FU) or capecitabine and want to know how your body will handle it. Some people carry genetic differences in the DPYD gene that make it hard to break down these drugs, which can lead to severe, even life-threatening side effects. Checking your DPYD status ahead of time helps identify this risk before treatment begins.

What's included in this test?

This test looks specifically at your DPYD gene to check for variants that affect how well your body processes certain chemotherapy drugs. Since it's a single, targeted genetic test rather than a panel of blood markers, the result is a straightforward genotype finding rather than a list of separate values.

What happens after I get my results?

Your results will show up in your account, with a clear explanation of what your specific DPYD gene variant status means. If a risk variant is found, the report outlines what that means for chemotherapy dosing conversations and next steps, and if results are normal, no special action is needed beyond noting it for your medical records. You can download a standard lab report from your account at any time, and since this is a one-time genetic test, there's no need to retest or track it over time like other blood work.

Who should consider this test?

Anyone scheduled to receive 5-fluorouracil, capecitabine, or related chemotherapy drugs for cancers like colorectal, breast, or head and neck cancer should consider this test. It's especially useful before treatment starts, since knowing your DPYD status in advance can prevent dangerous reactions. People with a family history of severe reactions to these chemotherapy drugs may also want to get tested.

When will I get my results?

Results are typically ready within about 7 days of your sample being processed at the lab. Because this test involves genetic analysis, it takes a bit longer than routine blood work. You'll be notified as soon as your results are available in your account.

What symptoms indicate I may need this test?

This test isn't about symptoms you're feeling right now — it's a preventive check done before starting certain chemotherapy drugs. However, if you or a family member has had severe reactions like extreme mouth sores, diarrhea, low blood cell counts, or infections during past 5-FU or capecitabine treatment, that history is a strong reason to get tested.

What is DPYD and why does it matter?

DPYD is a gene that gives instructions for making an enzyme your body needs to break down and clear certain chemotherapy drugs. If this enzyme doesn't work well due to gene variants, the chemotherapy drugs build up in your body instead of being cleared normally, which can cause severe toxicity. Knowing your DPYD status ahead of time helps guide safer chemotherapy planning.

What does an abnormal DPYD result mean?

An abnormal result means you carry a genetic variant that reduces your body's ability to break down certain chemotherapy drugs like 5-FU or capecitabine. This doesn't mean you can't receive these treatments, but it does mean extra caution, such as adjusted dosing, may be needed to reduce the risk of severe side effects. This information should be shared with your cancer treatment team before treatment starts.

What causes DPYD variants?

DPYD variants are inherited genetic differences passed down from your parents — they're not caused by lifestyle, diet, or anything you did. They're present from birth and don't change over time, which is why this is a one-time test rather than something you'd repeat. Some variants are more common in certain populations than others.

What should I do if my results show a DPYD variant?

If your results show a DPYD variant, don't panic — many people with variants still safely receive chemotherapy, often with adjusted doses or closer monitoring. Bring your results to your cancer treatment planning discussions so this information can factor into your treatment plan. Keep a copy of your report for your medical records since this information may be relevant for any future chemotherapy decisions.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

DPYD Genotype Test - Chemotherapy Safety Screening

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]

DPYD Gene Test for Chemotherapy Safety Screening

Dihydropyrimidine Dehydrogenase (DPYD) Genotype

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

What's this test for?

What's included in this test?

What happens after I get my results?

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

Find a lab near you

DPYD Gene Test for Chemotherapy Safety Screening

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

1,000,000+ blood tests later, here's what our customers say