What's this test for?

This test is ideal if you're experiencing unexplained blood clotting, easy bruising, fatigue, or if a recent blood count showed unusually high platelet levels. It helps identify a genetic change linked to myeloproliferative neoplasms, a group of conditions where your bone marrow makes too many blood cells. It's also useful if you've already been diagnosed with essential thrombocythemia or primary myelofibrosis and need to confirm the underlying genetic cause.

What's included in this test?

This test looks specifically at exon 9 of the CALR gene, a region where certain genetic changes are strongly linked to blood disorders that cause overproduction of blood cells. Detecting these changes helps explain symptoms like clotting, bruising, or abnormal blood counts, and clarifies which type of blood disorder may be present.

What happens after I get my results?

Your results will show up in your account along with an explanation of what a positive or negative finding means for this specific mutation. If a mutation is detected, the report outlines next steps like closer monitoring of your blood counts and discussing treatment options based on your specific results. You can download the full lab report from your account at any time, and if you retest in the future, the trends feature lets you track changes over time.

How can I naturally support healthy blood cell production?

While a CALR mutation itself can't be changed through lifestyle, you can support overall blood health by staying well hydrated, eating an iron-rich and antioxidant-rich diet, and avoiding smoking, which can worsen clotting risk. Regular light exercise like walking can also help circulation. These steps don't replace monitoring, but they support your body's overall resilience.

When will I get my results?

Results are typically ready within about 7 days of your sample being processed. Because this is a specialized DNA sequencing test, it takes a bit longer than routine bloodwork. You'll get a notification as soon as your results are available in your account.

Who should consider this test?

This test is a good fit for anyone with unexplained high platelet counts, unusual clotting or bleeding, or a family history of myeloproliferative blood conditions. It's also relevant if you've had a bone marrow biopsy suggesting essential thrombocythemia or primary myelofibrosis and want to confirm the specific genetic driver. People already diagnosed with a blood cell disorder but who tested negative for other common mutations may also consider this test.

What symptoms indicate I may need this test?

Common signs include unexplained blood clots, frequent headaches, dizziness, easy bruising or bleeding, fatigue, and an enlarged spleen. Some people notice tingling or burning in their hands and feet. If routine bloodwork showed very high platelet counts without an obvious cause, this test can help explain why.

What is a CALR mutation and why does it matter?

CALR is a gene that provides instructions for a protein involved in normal cell function. Certain mutations in this gene cause blood-forming cells in the bone marrow to grow and divide abnormally, leading to conditions like essential thrombocythemia or primary myelofibrosis. Identifying this mutation matters because it helps confirm the diagnosis and points toward the type of blood disorder involved.

What does a positive CALR mutation result mean?

A positive result means the specific genetic change was found in your blood or bone marrow cells, which is strongly associated with essential thrombocythemia or primary myelofibrosis. This doesn't tell you the severity of the condition, but it does confirm a genetic driver behind abnormal blood cell production. Your results report explains what this finding means and suggests appropriate next steps, including ongoing monitoring.

How often should I retest?

Retesting for the CALR mutation itself usually isn't needed once a mutation is confirmed, since it does not typically change over time. However, related blood counts like platelets should be monitored regularly, often every few months, depending on how your condition is being managed. Your care plan and symptom changes will guide how often you check in with follow-up bloodwork.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

CALR Mutation Test - Blood Disorder Screening

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

[email protected]

CALR Gene Mutation Test for Blood Disorders

Calreticulin (CALR) Mutation Analysis

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

What's this test for?

What's included in this test?

What happens after I get my results?

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CALR Gene Mutation Test for Blood Disorders

Prescription & all lab fees included

Doctor's guidance included

Fast & convenient

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