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Allergy testing for individuals unable to use traditional skin testing methods

Acetaminophen Allergy Test for Reactions and Symptoms

BasoFunction™ HRT Acetaminophen

Google
3,138 reviews
  • Pinpoint the cause of your fatigue
  • Reveal hidden hormone imbalances
  • Clarify how acetaminophen affects your body
First results as soon as overnight*

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you're experiencing allergic reactions or symptoms like hives, swelling, itching, or difficulty breathing after taking acetaminophen (Tylenol). It's designed for people who cannot undergo traditional skin allergy testing or standard IgE blood tests due to medications they're taking, skin conditions, or other medical reasons. This specialized test helps identify if your body's immune cells are reacting to acetaminophen, which can cause serious allergic reactions.

How should I prepare for this test?

If you're taking calcineurin inhibitors (like tacrolimus or cyclosporine), you'll need to stop taking them 72 hours before your blood draw. If you're on prednisone or other corticosteroids, you must stop the medication for 2 weeks prior to testing. These medications can interfere with your immune cell function and affect test accuracy. Always consult your prescribing doctor before stopping any medications.

What's included in this test?

BasoFunction™ HRT Acetaminophen

This test measures BasoFunction HRT Acetaminophen, which evaluates how your white blood cells (basophils) respond when exposed to acetaminophen in a controlled lab setting. By challenging your whole blood with histamine and the drug, this test reveals whether your immune cells release histamine in response to acetaminophen, indicating an allergic reaction. This specialized functional test provides valuable information when traditional allergy tests aren't suitable for your situation.

What happens after I get my results?
You'll receive detailed doctor notes in simple language explaining what your test results mean and whether your immune cells showed a reaction to acetaminophen. These notes include personalized recommendations on whether to avoid acetaminophen, safe alternative pain relievers to consider, and when you should follow up with an allergist. You'll also get the standard lab report and can track your allergy markers over time using our trends feature if you need repeat testing.
Who should consider getting this test?
This test is ideal for people who have experienced allergic symptoms after taking acetaminophen but cannot undergo skin prick testing due to medications like antihistamines, beta-blockers, or immunosuppressants. It's also suitable for individuals with severe skin conditions like eczema or dermatographism that make skin testing unreliable, pregnant women who need to avoid skin testing, or anyone whose doctor recommends blood-based allergy testing instead of traditional methods.
What symptoms indicate I may need this test?
You may need this test if you've experienced hives, skin rashes, facial swelling, or itching after taking acetaminophen or Tylenol products. More serious symptoms include difficulty breathing, wheezing, tightness in the chest, or rapid heartbeat following acetaminophen use. Even if you're unsure whether acetaminophen caused your symptoms, this test can help identify if your immune system reacts to this common pain reliever.
What is a BasoFunction test and why does it matter?
A BasoFunction test is a specialized blood test that measures how your basophils (a type of white blood cell) respond to specific substances like medications or allergens. Unlike standard allergy tests that look for antibodies, this test directly observes your immune cells' reaction in real-time by measuring histamine release. This matters because it can detect allergic reactions that other tests might miss, especially in people taking medications that interfere with traditional allergy testing.
What should I do if my results show a reaction to acetaminophen?
If your test shows a positive reaction to acetaminophen, avoid all products containing this ingredient, including Tylenol, many cold and flu medications, and combination pain relievers. Switch to alternative pain relievers like ibuprofen or naproxen if safe for you, always checking ingredient labels carefully. Inform all your healthcare providers about this allergy, consider wearing a medical alert bracelet, and discuss your results with an allergist who can provide comprehensive guidance on safe medication alternatives.
Can I take antihistamines before this test?
You should not take antihistamines before this test, as they can suppress your immune cells' ability to release histamine and may cause false-negative results. Your doctor will provide specific instructions on how long to stop antihistamines before testing, typically 3-7 days depending on the type. If you're taking antihistamines for severe allergies, discuss timing with your healthcare provider to ensure safe discontinuation while maintaining accurate test results.
How accurate is this test compared to skin testing?
BasoFunction testing offers a reliable alternative when skin testing isn't possible, with good accuracy for detecting drug allergies like acetaminophen sensitivity. While skin testing remains the gold standard when available, this blood test has the advantage of not being affected by skin conditions, doesn't require stopping antihistamines for as long, and can be performed safely in people with severe allergies. Your allergist can interpret results in the context of your symptoms and medical history for the most accurate assessment.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
BasoFunction HRT Acetaminophen Negative
Demo results
Negative Positive
Negative

What this means

Your test came back negative, meaning your basophils did not release histamine when exposed to acetaminophen in the lab. This suggests your immune system does not have an allergic reaction to acetaminophen, and it should be safe for you to use this pain reliever.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Acetaminophen Allergy Test for Reactions and Symptoms

Google
3,138 reviews
  • Pinpoint the cause of your fatigue
  • Reveal hidden hormone imbalances
  • Clarify how acetaminophen affects your body

1,000,000+ blood tests later, here's what our customers say

Google reviews 3138 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.