This test is ideal if you've experienced recurrent miscarriages, unexplained blood clots, or have been diagnosed with an autoimmune disorder like lupus. It helps identify antiphospholipid syndrome (APS), an autoimmune condition where your immune system mistakenly attacks proteins in your blood that affect clotting. Many people use this test when they've had pregnancy complications, stroke at a young age, or DVT/PE without clear cause and want to understand if an autoimmune clotting disorder is responsible.
What happens after I get my results?
You'll receive detailed doctor notes in simple language explaining what your antibody levels mean for your clotting risk and reproductive health. These notes include personalized recommendations about whether you need blood-thinning medications, aspirin therapy during pregnancy, or referral to a rheumatologist or hematologist. You'll also get the standard lab report and can track your antibody levels over time using our trends feature, which is especially important if you're managing APS or planning pregnancy.
Who should consider getting this test?
This test is essential for women who have had two or more unexplained miscarriages, especially in the second trimester, or anyone who's had blood clots at a young age without an obvious cause. It's also important if you have an autoimmune disease like lupus or Sjögren's syndrome, have had unexplained stroke or TIA, or have experienced late-pregnancy complications like preeclampsia or placental insufficiency. Your doctor may also recommend this if you've had a false-positive syphilis test, as this can indicate antiphospholipid antibodies.
What symptoms indicate I may need this test?
Key warning signs include experiencing multiple miscarriages (especially after 10 weeks of pregnancy), blood clots in your legs (DVT) or lungs (PE), unexplained stroke or mini-stroke at a young age, or livedo reticularis (a lacy, purplish pattern on your skin). You might also notice migraine headaches, memory problems, low platelet counts found on routine bloodwork, or heart valve abnormalities. If you have lupus or another autoimmune condition and experience any of these symptoms, this test is particularly important.
What is antiphospholipid syndrome and why does it matter?
Antiphospholipid syndrome (APS) is an autoimmune disorder where your body produces antibodies that attack phospholipids, which are proteins in your blood that help with normal clotting. This causes your blood to clot too easily in both arteries and veins, leading to serious complications like stroke, heart attack, DVT, pulmonary embolism, and recurrent pregnancy loss. It matters because APS is treatable with blood thinners and aspirin, and early diagnosis can prevent life-threatening clots and help women have successful pregnancies with proper management.
How can I naturally support healthy blood clotting?
While APS requires medical management with blood thinners if diagnosed, supporting overall vascular health can help. Stay well-hydrated, maintain a healthy weight, and engage in regular movement to promote good circulation. Incorporate anti-inflammatory foods like fatty fish, leafy greens, berries, and turmeric, while limiting processed foods. Avoid smoking, which significantly increases clotting risk. However, if you're diagnosed with APS, lifestyle changes alone are not sufficient—you'll need medical treatment with anticoagulants to prevent dangerous clots.
What does a positive result mean?
A positive result means antiphospholipid antibodies were detected in your blood. However, one positive test doesn't automatically mean you have antiphospholipid syndrome. These antibodies can temporarily appear during infections or with certain medications. To confirm APS diagnosis, you need a second positive test at least 12 weeks later, plus a history of blood clots or pregnancy complications. Your doctor will interpret your results in the context of your medical history and symptoms to determine if treatment is needed.
What causes antiphospholipid antibodies to develop?
The exact cause isn't fully understood, but antiphospholipid antibodies can develop due to genetic predisposition combined with environmental triggers. They're more common in people with autoimmune diseases like lupus, infections (including COVID-19, hepatitis C, and syphilis), and certain medications. Women are affected more often than men, and symptoms typically appear between ages 20 and 50. Some people have the antibodies temporarily without developing full APS, while others develop the chronic syndrome requiring long-term management.
How often should I retest for antiphospholipid antibodies?
If your first test is positive, you must retest at least 12 weeks (3 months) later to confirm the diagnosis, as temporary antibodies can appear with infections. If you're diagnosed with APS and on treatment, your doctor will monitor you regularly—typically every 3-6 months—to ensure your blood-thinning medication is working properly. If you had negative results but continue experiencing symptoms like recurrent miscarriage or unexplained clots, your doctor may recommend retesting, as antibodies can develop over time.
What should I do if my results are abnormal?
If antiphospholipid antibodies are detected, schedule a follow-up with your primary care doctor, rheumatologist, or hematologist to discuss your medical history and symptoms. You'll likely need repeat testing in 12 weeks to confirm the diagnosis. In the meantime, be aware of clotting symptoms like leg swelling, chest pain, or sudden shortness of breath, and seek immediate care if these occur. If you're planning pregnancy, discuss this with your OB-GYN, as you may need low-dose aspirin and blood thinners during pregnancy to prevent complications.
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Demo results
Anticardiolipin Antibody (IgG)Negative
Demo results
NegativePositive
Negative
What this means
Your anticardiolipin antibody test came back negative, meaning no significant autoantibodies were detected in your blood. This is the expected and healthy result, indicating you do not have elevated levels of these antibodies that increase clotting risk.
Recommended actions
If you have a history of miscarriage or clots, discuss other possible causes with your doctor
Maintain overall vascular health through regular exercise and a heart-healthy diet
If symptoms persist, consider retesting or additional clotting disorder screenings
Stay informed about warning signs of blood clots like leg swelling or chest pain
* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
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