High concentrations of acid phosphatase are found in the prostate gland. Significant amounts are also found in platelets, bone, spleen, kidney and liver. Prostatic Acid Phosphatase (PAP) is a component of total acid phosphates and is a major constituent in seminal fluid and is also secreted in the urine. PAP is normally found in serum in very low levels. PAP measurement has found clinical application in the management of prostatic cancer patients. Serum PAP measurements have been useful in monitoring remission or relapse of a prostatic malignancy and in assessing the effectiveness of various treatment regimes. Thus, normalization in serum PAP levels has been observed following successful therapeutic intervention, while recurrent or residual disease has been associated with elevated levels of PAP.
Significant deviations from the normal range may require further evaluation by your physician.
Prostatic Acid Phosphatase (PAP), Serum
Samples must be obtained before rectal examination, biopsy, prostatectomy or prostatic massage, since manipulating the prostate gland may lead to elevated PAP levels persisting up to 24-48 hours.
Estimated turnaround for results is 5 business days.