Alanine Aminotransferase (ALT) measurements are particularly useful in the diagnosis and management of certain liver diseases, e.g., viral hepatitis and cirrhosis. ALT activity in tissue is generally much lower than aspartate aminotransferase (AST) activity and is found in highest concentrations in the liver. Significant elevations of ALT occur only in diseases of the liver. ALT is often measured in conjunction with AST to determine whether the source of the AST is the liver or the heart. ALT is normally not elevated in cases of myocardial infarction, i.e., a normal ALT, in conjunction with an elevated AST, tends to suggest cardiac disease. However, slight elevations of ALT may occur if an infarct destroys a very large volume of heart muscle.
Alanine Aminotransferase (ALT/SGPT)
****Alanine Aminotransferase (ALT/SGPT) is included in the Comprehensive Metabolic Profile (CMP) and in the Liver Function Profile.***
No fasting required.
Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.
A liver function test, ALT is more sensitive for the detection of hepatocyte injury than for biliary obstruction. ALT is more specific for liver injury than AST (SGOT). Useful for hepatic cirrhosis, other liver disease. Increased in Reye syndrome, with AST. Test for hepatitis. Acute hepatitis A or B can be confirmed serologically, as can hepatitis C. Negative serological findings in the presence of hepatitis-like chemistry abnormalities may also suggest acute drug-induced hepatitis, an impression supported by resolution after removal of the offending agent. The combination of increased AST and ALT with negative hepatitis markers occurs in a number of other entities including infectious mononucleosis. Sensitive to heart failure.
Alanine Aminotransferase (ALT/SGPT)
****Alanine Aminotransferase (ALT/SGPT) is included in the Comprehensive Metabolic Profile (CMP) and in the Liver Function Profile****
No fasting required.
Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.
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