Measurement of the levels of bilirubin is used in the diagnosis and treatment of liver, hemolytic, hematologic, and metabolic disorders, including hepatitis and gall bladder obstruction. The assessment of direct bilirubin is helpful in the differentiation of hepatic disorders. The increase in total bilirubin associated with obstructive jaundice is primarily due to the direct (conjugated) fraction. Both direct and indirect bilirubin are increased in the serum with hepatitis.
Alternative Names(s): Conjugated Bilirubin
A significant deviation from the normal range may require further evaluation by your physician.
Bilirubin, Direct
***Bilirubin Direct is included in the Liver Function Profile.***
No fasting required.
Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.
Evaluate liver and biliary disease. Increased direct bilirubin occurs with biliary diseases, including both intrahepatic and extrahepatic lesions. Hepatocellular causes of elevation include hepatitis, cirrhosis, and advanced neoplastic states. Increased with cholestatic drug reactions, Dubin-Johnson syndrome, and Rotor syndrome. In the latter two syndromes, the level is usually <5 mg/dL.
Bilirubin, Direct
***Bilirubin Direct is included in the Liver Function Profile.****
No fasting required.
Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.