Understanding Lab Tests for Itai-itai Disease
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Itai-itai disease is a severe form of chronic cadmium poisoning that causes excruciating pain in the bones and joints, particularly affecting the spine. This condition was first identified in Japan and results from long-term exposure to cadmium, typically through contaminated water or food sources.
Recommended Test
Heavy Metals Panel, Random Urine
This comprehensive test measures cadmium levels along with other heavy metals in urine. Elevated cadmium concentrations in urine are a key diagnostic marker for Itai-itai disease, as they indicate long-term cadmium accumulation in the body that leads to the characteristic severe bone and joint pain.
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Diagnosing Itai-itai Disease
While the characteristic bone pain and symptoms may suggest cadmium toxicity, a definitive diagnosis of Itai-itai disease requires laboratory confirmation of elevated cadmium levels in the body. Blood tests measuring cadmium levels are essential for establishing the diagnosis and determining the extent of exposure.
Understanding Cadmium Toxicity
Cadmium is a toxic heavy metal that accumulates in the kidneys and bones over time. Chronic exposure can lead to kidney dysfunction, bone demineralization, and the severe pain syndrome known as Itai-itai disease. Early detection through testing is crucial for preventing progression and managing symptoms.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
