Question 1

What is Gilbert's Syndrome?

Accepted Answer

Gilbert's Syndrome is a common, benign genetic condition affecting how the liver processes bilirubin, a yellow compound produced when red blood cells break down. It is caused by a mutation in the UGT1A1 gene that reduces the liver's ability to conjugate bilirubin effectively. The Bilirubin, Total test is the most important test for diagnosis as it reveals the characteristic elevated bilirubin levels that confirm this condition.

Question 2

What causes Gilbert's Syndrome?

Accepted Answer

Gilbert's Syndrome is caused by a genetic mutation in the UGT1A1 gene that reduces the production of an enzyme called UDP-glucuronosyltransferase. This enzyme is responsible for processing bilirubin in the liver by converting it from its indirect (unconjugated) form to its direct (conjugated) form so it can be eliminated from the body. When this enzyme is reduced by about 70%, bilirubin builds up in the bloodstream, leading to mildly elevated levels that can cause occasional jaundice, especially during times of stress, fasting, or illness.

Question 3

What is the best test for Gilbert's Syndrome?

Accepted Answer

The Bilirubin, Total test is the most important test for Gilbert's Syndrome because it reveals elevated total bilirubin levels, which is the hallmark of this condition. A comprehensive diagnosis typically includes the Bilirubin, Direct test to confirm that direct bilirubin remains normal while indirect bilirubin is elevated, creating the characteristic pattern that distinguishes Gilbert's Syndrome from other liver disorders. The Liver Function Profile provides additional confirmation by showing that other liver enzymes remain normal despite the elevated indirect bilirubin, which reassures both patients and doctors that the condition is benign and not a sign of serious liver disease.

Question 4

When should I get tested for Gilbert's Syndrome?

Accepted Answer

You should get tested if you notice your skin or the whites of your eyes turning slightly yellow (jaundice), especially after periods of fasting, stress, illness, or intense exercise. Testing is also recommended if you have unexplained fatigue or if routine blood work shows mildly elevated bilirubin levels that your doctor wants to investigate further. Many people discover they have Gilbert's Syndrome incidentally during blood tests for other reasons, so if you have a family history of the condition or experience recurring mild jaundice, getting tested can provide clarity and peace of mind.

Question 5

What are the symptoms of Gilbert's Syndrome?

Accepted Answer

Most people with Gilbert's Syndrome have no symptoms at all and live normal, healthy lives without knowing they have the condition. When symptoms do occur, the most common is mild jaundice, where the skin and whites of the eyes take on a slightly yellow tint. Some people report feeling tired or experiencing mild abdominal discomfort, though these symptoms are often triggered by specific circumstances like skipping meals, being sick with a cold or flu, experiencing stress, or exercising intensely. The symptoms are typically temporary and resolve on their own without treatment.

Question 6

Who is at risk for Gilbert's Syndrome?

Accepted Answer

Gilbert's Syndrome is an inherited condition that affects about 3-7% of the population, making it relatively common. You are at higher risk if you have family members with the condition since it follows an autosomal recessive inheritance pattern, meaning you need to inherit the gene mutation from both parents. The condition is more commonly diagnosed in males than females and typically becomes noticeable during the teenage years or early adulthood. People of all ethnic backgrounds can have Gilbert's Syndrome, though it appears to be slightly more common in certain populations.

Question 7

What happens if Gilbert's Syndrome is left untreated?

Accepted Answer

Gilbert's Syndrome is a completely benign condition that does not cause liver damage or lead to serious health problems, so leaving it untreated poses no significant health risks. Most people with the condition live normal lifespans without complications and do not require any medical treatment. The main reason to confirm the diagnosis is for peace of mind and to avoid unnecessary testing or concern when mild jaundice appears or when routine blood work shows elevated bilirubin. Knowing you have Gilbert's Syndrome can also help your doctors interpret future lab results correctly and avoid mistaking it for a more serious liver condition.

Question 8

Can Gilbert's Syndrome be diagnosed with a blood test?

Accepted Answer

Yes, Gilbert's Syndrome is diagnosed primarily through blood tests that measure bilirubin levels in your bloodstream. The blood work will show elevated total bilirubin with most of the elevation coming from indirect (unconjugated) bilirubin, while direct bilirubin and other liver enzymes remain normal. This specific pattern of results is highly characteristic of Gilbert's Syndrome and helps doctors distinguish it from other liver conditions. Some doctors may also order genetic testing to confirm the UGT1A1 gene mutation, though this is usually not necessary if the blood test results show the typical pattern.

Question 9

How is Gilbert's Syndrome treated?

Accepted Answer

Gilbert's Syndrome requires no medical treatment because it is a benign condition that does not damage the liver or cause serious health problems. The main approach is simply managing any triggers that might cause bilirubin levels to rise temporarily, such as avoiding prolonged fasting, staying well-hydrated, managing stress, and getting adequate rest during illness. If mild jaundice appears during stressful periods or illness, it will typically resolve on its own within a few days without intervention. Some medications can raise bilirubin levels in people with Gilbert's Syndrome, so it is important to inform your doctors and pharmacists about your condition when being prescribed new medications.

Question 10

How can I prevent Gilbert's Syndrome?

Accepted Answer

Gilbert's Syndrome cannot be prevented because it is an inherited genetic condition that you are born with. However, you can prevent episodes of elevated bilirubin and jaundice by avoiding known triggers such as fasting for long periods, becoming dehydrated, or putting your body under extreme stress. Eating regular meals, staying hydrated, getting enough sleep, and managing stress levels can help keep your bilirubin levels more stable. While you cannot change the underlying genetic cause, these lifestyle measures can minimize the visible symptoms and help you feel your best.

Question 11

What natural remedies help with Gilbert's Syndrome?

Accepted Answer

While no natural remedies can cure Gilbert's Syndrome, certain lifestyle approaches can help manage the condition and reduce the frequency of jaundice episodes. Eating regular, balanced meals prevents the fasting-induced spikes in bilirubin that often trigger symptoms. Staying well-hydrated helps your body process and eliminate bilirubin more effectively. Some people find that milk thistle supplements support overall liver health, though scientific evidence specifically for Gilbert's Syndrome is limited. Managing stress through techniques like meditation, yoga, or regular exercise can also help minimize symptom flare-ups, and getting adequate sleep gives your liver time to function optimally.

Question 12

How’s this work?

Accepted Answer

Getting your blood test with us is easy, private & backed by the power of science.Long story short:
            
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Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
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Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
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Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
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Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
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Question 17

Can I cancel my order?

Accepted Answer

Yes.
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Question 18

How can I find a lab location near me?

Accepted Answer

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached!
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Gilbert's Syndrome Blood Test

What is Gilbert's Syndrome?

What causes Gilbert's Syndrome?

What is the best test for Gilbert's Syndrome?

When should I get tested for Gilbert's Syndrome?

References

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