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Gastroesophageal Reflux Disease (GERD) is a chronic digestive condition where stomach acid frequently flows back into the esophagus, causing heartburn and chest discomfort. It is caused by a weakened lower esophageal sphincter that fails to prevent stomach acid from rising, often worsened by excess acid production from elevated gastrin or histamine levels. The Gastrin blood test is the most important test for GERD because it identifies whether excessive gastrin hormone is stimulating overproduction of stomach acid.
GERD is caused by a weakened or malfunctioning lower esophageal sphincter (LES), the muscle valve that separates your esophagus from your stomach. When this valve doesn't close properly, stomach acid and digestive contents can flow backward into the esophagus, causing the burning sensation known as heartburn. Several factors can worsen this condition, including excess production of stomach acid triggered by elevated levels of gastrin or histamine hormones, obesity that puts pressure on the stomach, hiatal hernias, pregnancy, smoking, and certain foods like fatty meals, chocolate, caffeine, and alcohol.
The Gastrin blood test is the most important test for GERD because it measures the hormone responsible for stimulating stomach acid production. Elevated gastrin levels can cause your stomach to produce excessive amounts of acid, making your reflux symptoms worse and harder to control with standard treatments. The Histamine Plasma test is also essential because histamine stimulates acid-producing cells in your stomach lining, and high levels can lead to more frequent and severe acid reflux episodes. While GERD is primarily diagnosed through your symptoms and clinical examination, these blood tests help identify underlying biochemical reasons why you might be producing too much stomach acid, allowing your doctor to develop a more targeted treatment plan.
You should get tested if you experience heartburn or acid reflux more than twice a week, have difficulty swallowing, feel like food is stuck in your throat, or wake up with a sour taste in your mouth. Get tested immediately if standard GERD medications aren't providing relief, you're experiencing unexplained weight loss, you have chest pain that's not related to your heart, or you notice blood in your vomit or stool. Testing is especially important if your symptoms have been ongoing for several weeks or are getting worse, as chronic acid exposure can damage your esophagus and lead to more serious complications.
What this means
Your gastrin level is slightly elevated above the optimal range. While this is not necessarily alarming, it may indicate your stomach is producing excess acid, which could contribute to heartburn, stomach pain, or digestive discomfort you've been experiencing.
Recommended actions
Avoid foods that trigger acid production like spicy foods, caffeine, and alcohol
Eat smaller, more frequent meals rather than large portions
Discuss with your doctor about temporarily stopping acid-reducing medications before retesting
Consider retesting in 8-12 weeks to monitor trends
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