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Gastric ulcers are open sores that develop in the stomach lining due to damage from digestive acids. They are caused by Helicobacter pylori bacterial infection, overuse of NSAIDs, or excessive stomach acid production from elevated gastrin hormone levels. The Gastrin blood test is the most important test for identifying hormonal causes of gastric ulcers.
Gastric ulcers are caused by three primary factors that damage the stomach lining. The most common cause is infection with Helicobacter pylori bacteria, which weakens the protective mucus layer of the stomach. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen can also erode the stomach lining and trigger ulcer formation. Additionally, conditions that cause excessive gastrin hormone production, such as Zollinger-Ellison syndrome, lead to overproduction of stomach acid that damages stomach tissue.
The Gastrin blood test is the most important test for identifying hormonal causes of gastric ulcers because it measures levels of gastrin, the hormone responsible for stimulating stomach acid production. Elevated gastrin levels indicate conditions like Zollinger-Ellison syndrome or other disorders causing excessive acid that contributes to ulcer formation. While gastric ulcers are primarily diagnosed through endoscopy or imaging studies, the Gastrin test helps healthcare providers understand whether hormonal imbalances are driving the condition and guides targeted treatment strategies. Testing for H. pylori infection through blood tests, breath tests, or stool samples is also essential since this bacteria causes the majority of gastric ulcers.
You should get tested if you experience burning stomach pain that comes and goes, especially between meals or at night, or if antacids temporarily relieve your discomfort. Consider testing if you have unexplained weight loss, persistent nausea or vomiting, blood in your stool or dark tarry stools, or if you take NSAIDs regularly and develop stomach pain. Getting tested is especially important if you have a family history of stomach problems or if you experience severe, sudden abdominal pain that could indicate a perforated ulcer requiring emergency care.
What this means
Your gastrin level is slightly elevated above the optimal range. While this is not necessarily alarming, it may indicate your stomach is producing excess acid, which could contribute to heartburn, stomach pain, or digestive discomfort you've been experiencing.
Recommended actions
Avoid foods that trigger acid production like spicy foods, caffeine, and alcohol
Eat smaller, more frequent meals rather than large portions
Discuss with your doctor about temporarily stopping acid-reducing medications before retesting
Consider retesting in 8-12 weeks to monitor trends
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