Chronic hepatitis is long-term inflammation of the liver that persists for at least six months. It is caused by viral infections like hepatitis B and C, autoimmune disorders, or prolonged exposure to toxins and alcohol. The Hepatitis Panel Acute with Reflex Confirmation is the most important test for diagnosing chronic hepatitis because it detects viral markers and confirms persistent infection.
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Chronic hepatitis is caused by viral infections, primarily hepatitis B virus (HBV) and hepatitis C virus (HCV), which account for most cases worldwide. These viruses attack liver cells and trigger ongoing inflammation that can last for years or even decades. Other causes include autoimmune hepatitis where your immune system mistakenly attacks liver tissue, prolonged alcohol abuse, certain medications, and metabolic disorders like non-alcoholic fatty liver disease. The viral forms are particularly concerning because they can silently damage your liver over time without obvious symptoms until significant scarring has occurred.
The Hepatitis Panel Acute with Reflex Confirmation is the most important test for chronic hepatitis because it detects specific viral markers that indicate whether hepatitis B or C viruses are present in your blood. This comprehensive panel measures antibodies and antigens that reveal both current infection and your immune response, with reflex testing providing confirmation when initial results show viral activity. A moderate index value indicates your body has not been able to clear the virus, signaling a chronic infection that requires monitoring. Additional tests like the Rheumatoid Factor test can help assess the inflammatory impact on your body, as elevated rheumatoid factor levels often appear in chronic hepatitis patients and indicate systemic inflammation that may affect multiple organs beyond the liver.
You should get tested if you have persistent fatigue, unexplained weight loss, abdominal pain or discomfort in your upper right side, yellowing of your skin or eyes, or dark urine lasting more than a few weeks. Testing is also crucial if you have a history of injection drug use, received blood transfusions before 1992, were born to a mother with hepatitis, have had unprotected sex with multiple partners, or work in healthcare with potential exposure to blood. Early detection through blood testing is essential because chronic hepatitis often has no symptoms in its early stages, yet the virus continues damaging your liver and can progress to cirrhosis or liver cancer if left untreated.
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What this means
Your test came back negative, meaning no Hepatitis B surface antigen was detected in your blood. This is the expected and healthy result, indicating you do not have an active Hepatitis B infection.
Recommended actions
Consider Hepatitis B vaccination if not already vaccinated for long-term protection
Practice safe sex and avoid sharing needles or personal care items
If you have ongoing liver symptoms, discuss additional liver function tests with your doctor
Retest if you have potential exposure or work in high-risk environments
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