Understanding Lab Tests for C3 Deficiency
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
C3 deficiency is a rare inherited immune system disorder that affects the complement system, a crucial part of the body's defense against infections. This condition is characterized by significantly low levels of complement component C3, leading to increased susceptibility to recurrent bacterial infections.
Recommended Test
Complement Component C3c and C4c
This blood test directly measures the levels of complement components C3c and C4c in the serum. In C3 deficiency, C3c levels will be significantly reduced or absent, confirming the diagnosis of this rare immune system disorder that predisposes individuals to recurrent bacterial infections.
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Diagnosing C3 Deficiency
Because C3 deficiency can present with symptoms similar to other immune disorders, accurate diagnosis requires specific blood testing to measure complement component levels. Early detection is essential for implementing appropriate treatment strategies and preventing serious infections.
Understanding the Complement System
The complement system consists of proteins that work together to enhance the immune system's ability to fight infections. C3 is one of the most abundant and important complement proteins, playing a central role in identifying and eliminating harmful bacteria. When C3 levels are deficient, the body's ability to combat bacterial infections is significantly compromised.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
