Understanding Lab Tests for Behcet's Disease
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Behcet's Disease is a rare, chronic inflammatory disorder that causes blood vessel inflammation (vasculitis) throughout the body. There is no single blood test that can definitively diagnose Behcet's Disease, as diagnosis is primarily based on clinical symptoms and criteria. However, laboratory testing plays a fundamental supporting role in assessing genetic susceptibility, monitoring inflammatory activity, and identifying potential complications.
Top Recommended Test
Cardiolipin Antibodies (IgA, IgG, IgM)
This test detects antibodies associated with vascular involvement and disease activity in Behcet's Disease. Since Behcet's is a systemic vasculitis affecting blood vessels, the presence of these antibodies can help assess the extent of vascular complications and monitor disease progression.
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Why Blood Testing is Important for Behcet's Disease
While the diagnosis of Behcet's Disease relies on clinical presentation and established criteria, blood tests are essential for evaluating the body's immune response, identifying inflammatory markers, assessing genetic predisposition, and monitoring disease activity. These tests help healthcare providers develop comprehensive treatment plans and track the condition's progression.
Other Relevant Tests
Saccharomyces cerevisiae Antibodies (ASCA) (IgG)
Research has shown increased levels of ASCA IgG in patients with Behcet's Disease, suggesting these antibodies may play a role in the inflammatory processes characteristic of this condition. This test can provide insight into the immune system's activity.
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Saccharomyces cerevisiae Antibodies (ASCA) (IgA)
ASCA IgA may be present in patients with Behcet's Disease and can specifically indicate intestinal involvement, which is one of the potential manifestations of this systemic inflammatory disorder.
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Interleukin 17, Serum
This test measures levels of Interleukin 17, a key inflammatory marker that may be elevated in Behcet's Disease. Increased levels of this cytokine are believed to be involved in the disease's pathogenesis and can help assess inflammatory activity.
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HLA-A, B, C, DRB1 and DQ High Resolution
This genetic test identifies HLA markers, particularly HLA-B51/B5, which are associated with increased susceptibility to Behcet's Disease. While not diagnostic, this test can provide valuable information about genetic predisposition and help support clinical assessment.
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Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Behcet's Disease diagnosis requires comprehensive clinical evaluation by a healthcare provider familiar with the condition. Always consult with a healthcare provider for proper diagnosis and treatment.
