Sample results
Bacterial infections occur when harmful bacteria invade the body and multiply, affecting various organs and systems. They are caused by pathogenic bacteria such as Staphylococcus aureus, Streptococcus species, Escherichia coli, and other bacterial organisms that trigger immune system activation. The Complement Component C3c and C4c test is the most important test for assessing immune response during bacterial infections because it measures complement system activation.
Bacterial infections are caused by pathogenic bacteria entering the body through cuts, contaminated food or water, respiratory droplets, or sexual contact. Common bacterial culprits include Staphylococcus aureus (causing skin infections and pneumonia), Streptococcus species (causing strep throat and skin infections), Escherichia coli (causing urinary tract and gastrointestinal infections), Salmonella (causing food poisoning), and Mycobacterium tuberculosis (causing tuberculosis). These bacteria multiply rapidly once inside the body, releasing toxins and triggering an immune response that leads to inflammation, fever, and other symptoms depending on which organ system is affected.
The Complement Component C3c and C4c test is the most important blood test for assessing immune response during bacterial infections because it measures how actively your immune system is fighting the infection. This test detects elevation in complement proteins, particularly C3c, which rise as part of the body's defense mechanism against bacterial invaders. The Complement Component C3c test alone can also measure immune system activity, while the ANA Screen IFA test helps identify current or past bacterial infections by detecting antibodies. These blood tests work alongside bacterial cultures and antigen detection tests to give a complete picture of infection status and immune response.
You should get tested if you experience persistent fever above 101°F, signs of infection like redness, swelling, warmth, or pus at a wound site, unexplained fatigue lasting more than a few days, or symptoms like persistent cough, painful urination, or severe diarrhea. Testing is especially important if you have a weakened immune system, diabetes, or other chronic conditions that make you more vulnerable to infections. Get tested promptly if symptoms worsen rapidly or you develop confusion, difficulty breathing, or severe pain, as these may indicate a serious bacterial infection requiring immediate treatment.
What this means
Your C3 complement levels are below the optimal range, which may indicate your immune system is consuming complement proteins faster than normal, often seen in autoimmune activity or chronic infections. Low C3 can make you more susceptible to infections and may explain frequent illness or prolonged recovery times.
Recommended actions
Follow up with your healthcare provider or rheumatologist to investigate underlying causes
Support immune health with adequate sleep, stress management, and a nutrient-rich diet
Avoid smoking and limit alcohol, which can further compromise immune function
Retest in 6-8 weeks to monitor trends and track any treatment response
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Sample results
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