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TSI test for diagnosing Graves' disease and hyperthyroid symptoms like fatigue

Blood Test for Unexplained Weight Loss and Rapid Heartbeat

Thyroid-Stimulating Immunoglobulin (TSI)

Google
3,138 reviews
  • Pinpoint the cause of your fatigue
  • Reveal hidden thyroid issues effortlessly
  • Clarify the reason behind weight changes
First results as soon as overnight*

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you're experiencing unexplained symptoms of an overactive thyroid, such as persistent fatigue, unexplained weight loss, rapid heartbeat, anxiety, or heat intolerance. It specifically helps diagnose Graves' disease, which is an autoimmune condition where your immune system mistakenly stimulates your thyroid to produce too much hormone. This test is particularly valuable if standard thyroid tests suggest hyperthyroidism but your doctor needs to pinpoint whether it's caused by Graves' disease specifically.

How should I prepare for this test?

No special preparation is typically required for this test. Results are usually available within 7 business days, though if confirmation testing is needed, the timeframe may be extended. You can take your regular medications and eat normally before the test unless your doctor provides different instructions.

What's included in this test?

TSI

This test measures Thyroid-Stimulating Immunoglobulin (TSI), which are antibodies produced by your immune system that can overstimulate your thyroid gland. High TSI levels are the hallmark of Graves' disease and help explain symptoms like anxiety, weight loss, rapid heartbeat, and fatigue. This measurement helps your doctor determine if your hyperthyroid symptoms are caused by an autoimmune condition and whether antithyroid drug therapy will be effective for you.

What happens after I get my results?
You'll receive detailed doctor notes in simple language explaining what your TSI levels mean and whether they indicate Graves' disease or another cause of hyperthyroidism. These notes include personalized recommendations like whether you may need antithyroid medication, lifestyle adjustments to manage symptoms, or follow-up with an endocrinologist. You'll also get the standard lab report and can track your TSI levels over time using our trends feature, which is especially helpful if you're undergoing treatment or monitoring disease activity.
When will I get my results?
You can expect your results within approximately 7 business days from when your sample reaches the lab. In some cases, if confirmation testing is required to ensure accuracy, the turnaround time may be extended. You'll be notified as soon as your results are ready to view in your secure online account.
Who should consider getting this test?
This test is important for anyone who has been diagnosed with hyperthyroidism and needs to determine if Graves' disease is the cause. It's especially useful if you're considering antithyroid drug therapy, as markedly elevated TSI levels may indicate you won't respond well to this treatment. You should also consider this test if you have symptoms of overactive thyroid like unexplained weight loss, rapid heartbeat, tremors, or bulging eyes, particularly if you have a family history of autoimmune thyroid disease.
What symptoms indicate I may need this test?
You may need this test if you're experiencing symptoms of hyperthyroidism such as unexplained weight loss despite eating normally, rapid or irregular heartbeat, feeling anxious or irritable, trembling hands, excessive sweating, or difficulty sleeping. Other signs include feeling unusually warm or heat-intolerant, muscle weakness, more frequent bowel movements, and changes in your eyes like bulging or irritation. Women may also notice lighter or irregular periods.
How can I naturally support my thyroid health with Graves' disease?
While Graves' disease typically requires medical treatment, you can support your overall thyroid health through stress management techniques like meditation, deep breathing, or yoga, as stress can worsen symptoms. Eating a balanced diet rich in selenium (Brazil nuts, eggs, fish) and avoiding excessive iodine may help. Getting adequate rest, limiting caffeine and stimulants that can worsen rapid heartbeat, and avoiding smoking are also important, as smoking can worsen eye symptoms associated with Graves' disease.
What is TSI and why does it matter?
TSI stands for Thyroid-Stimulating Immunoglobulin, which are antibodies your immune system produces when you have Graves' disease. Unlike normal thyroid regulation, these antibodies bind to your thyroid cells and constantly stimulate them to produce too much thyroid hormone, causing hyperthyroidism. TSI levels matter because they're the specific marker that distinguishes Graves' disease from other causes of an overactive thyroid, and high levels can help predict how well you'll respond to different treatments.
What does high TSI mean?
High TSI levels confirm that you have Graves' disease, an autoimmune condition causing your thyroid to be overactive. Markedly elevated TSI can indicate that antithyroid medications may be less effective for you, and alternative treatments like radioactive iodine or surgery might be considered. High TSI is also associated with more active disease and may correlate with symptoms like rapid heartbeat, weight loss, and in some cases, the eye changes characteristic of Graves' disease.
How often should I retest my TSI levels?
If you're being treated for Graves' disease, your doctor will typically monitor your TSI levels periodically to assess disease activity and treatment response. TSI may be retested every few months during active treatment, and before considering stopping antithyroid medication to predict the likelihood of remission. Once your condition is stable or in remission, less frequent monitoring may be needed, though your doctor will determine the best schedule based on your individual situation.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
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Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Thyroid-Stimulating Immunoglobulin (TSI) 2.8 IU/L
Demo results
Normal < 1.75 Elevated ≥ 1.75
2.8 IU/L

What this means

Your TSI level is elevated, which confirms the presence of Graves' disease antibodies that are overstimulating your thyroid gland. This explains symptoms like unexplained weight loss, rapid heartbeat, anxiety, or heat intolerance you may be experiencing. Elevated TSI indicates active autoimmune thyroid stimulation that typically requires medical treatment.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
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Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
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Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Blood Test for Unexplained Weight Loss and Rapid Heartbeat

Google
3,138 reviews
  • Pinpoint the cause of your fatigue
  • Reveal hidden thyroid issues effortlessly
  • Clarify the reason behind weight changes

1,000,000+ blood tests later, here's what our customers say

Google reviews 3138 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.