What happens after I get my results?

You'll receive detailed doctor notes in simple language explaining what your MTHFR genetic variants mean for your health and whether they may be contributing to your symptoms. These notes include personalized recommendations like specific B-vitamin supplementation strategies, dietary changes to support methylation, and whether you should monitor homocysteine levels. You'll also get the standard lab report, and since this is a one-time genetic test, your results provide permanent insights you can use throughout your life when making health decisions.

Who should consider getting this test?

This test is valuable for people with unexplained chronic fatigue, persistent mood issues like anxiety or depression, or a family history of heart disease or blood clotting disorders. It's also helpful for women who have experienced recurrent miscarriages, individuals with elevated homocysteine levels, or anyone who hasn't responded well to standard B-vitamin supplements. People with autoimmune conditions or those planning pregnancy may also benefit from understanding their MTHFR status.

What symptoms indicate I may need this test?

Common symptoms that may be related to MTHFR variants include persistent fatigue that doesn't improve with rest, difficulty concentrating or brain fog, mood swings or anxiety, and unexplained irritability. You might also experience headaches or migraines, difficulty getting pregnant or maintaining pregnancy, or have concerns about cardiovascular health. If these symptoms are present along with a family history of heart disease, stroke, or blood clots, this test can provide valuable genetic insights.

How can I naturally support my MTHFR gene function?

If you have MTHFR variants, focus on consuming methylated forms of B vitamins like methylfolate (not regular folic acid) and methylcobalamin (B12) through supplements or fortified foods. Eat plenty of leafy greens, legumes, and whole foods rich in natural folate, and include B6 sources like chickpeas, salmon, and poultry. Reduce stress through regular exercise and adequate sleep, limit alcohol consumption, and avoid processed foods high in synthetic folic acid which may be harder for your body to process.

What is the MTHFR gene and why does it matter?

The MTHFR gene provides instructions for making an enzyme that helps your body process folate (vitamin B9) and convert it into a usable form. This enzyme is crucial for producing neurotransmitters that affect mood, creating DNA, and breaking down homocysteine, an amino acid that at high levels can damage blood vessels. When you have MTHFR gene variants, this enzyme works less efficiently, potentially affecting energy production, mental health, pregnancy outcomes, and cardiovascular health over time.

What does it mean if I have MTHFR mutations?

Having MTHFR mutations means your body may be less efficient at converting folate into its active form and processing homocysteine. If you have one copy of a variant (heterozygous), the impact is typically mild and manageable with dietary adjustments. If you have two copies (homozygous) or variants in both genes (compound heterozygous), enzyme activity may be more significantly reduced, potentially requiring methylated B-vitamin supplementation and closer monitoring of homocysteine levels.

What should I do if my MTHFR test is positive for variants?

If you test positive for MTHFR variants, start by switching to methylated forms of B vitamins rather than synthetic folic acid. Consider having your homocysteine levels tested to see if they're elevated, as this helps determine if the genetic variant is actually impacting your health. Work with a healthcare provider familiar with MTHFR to develop a personalized supplement and nutrition plan, and focus on eating whole foods rich in natural folate while managing stress and maintaining a healthy lifestyle.