JAK2 V617F Mutation Analysis
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Blood Test for Abnormal Blood Cell Growth and Blood Disorders
JAK2 V617F Mutation Analysis
- Detects a specific gene mutation.
- Checks for blood disorder signs.
- Identifies abnormal cell growth indicators.
$2098
Example results
First results as soon as overnight*
90 day happiness guarantee
We stand behind our service
Prescription & fees included
Go directly to the lab, no extra fees
Easy to understand results
With friendly doctor's notes & guidance
Fast & convenient
Lab visit as quick as 10 mins in & out
90 day happiness guarantee
We stand behind our service
Prescription & fees included
Go directly to the lab, no extra fees
Easy to understand results
With friendly doctor's notes & guidance
Fast & convenient
Lab visit as quick as 10 mins in & out
What's this test for?
This test is ideal if you're experiencing unexplained high red blood cell counts, abnormal platelet levels, or enlarged spleen. It helps identify specific blood disorders called myeloproliferative neoplasms, which cause your bone marrow to produce too many blood cells. Many people use this test when their doctor suspects conditions like polycythemia vera or essential thrombocythemia based on routine blood work abnormalities.
What's included in this test?
This specialized genetic test analyzes your white blood cells or bone marrow for a specific mutation at codon 617 of the JAK2 gene. This mutation is strongly associated with myeloproliferative neoplasms, which are blood disorders that cause abnormal production of blood cells. Detecting this mutation helps doctors diagnose conditions like polycythemia vera, essential thrombocythemia, and primary myelofibrosis, and guides appropriate treatment decisions.
What happens after I get my results?
You'll receive detailed doctor notes in simple language explaining what your genetic test results mean and whether the JAK2 mutation was detected. These notes include personalized guidance on next steps, whether that's monitoring your blood counts more closely, discussing treatment options with a hematologist, or understanding what this means for your long-term health. You'll also get the standard lab report and can track your results over time if you need follow-up testing.
Who should consider this test?
This test is recommended for people with abnormal blood counts that suggest a myeloproliferative disorder, such as persistently elevated red blood cells, white blood cells, or platelets. It's also important if you have an enlarged spleen, unexplained blood clots, or symptoms like itching after bathing, excessive sweating, or facial redness. Your doctor may order this test if routine blood work shows patterns consistent with these conditions.
What symptoms indicate I may need this test?
Common symptoms include unexplained fatigue, headaches, dizziness, vision changes, or excessive sweating. You might also experience itching especially after warm baths, facial redness or flushing, enlarged spleen causing abdominal discomfort, or unexpected blood clots. Some people have no symptoms and are only identified through routine blood work showing abnormal cell counts.
What does a positive JAK2 V617F mutation mean?
A positive result means the JAK2 V617F mutation was detected in your blood cells, which is found in about 95% of people with polycythemia vera and 50-60% of those with essential thrombocythemia or primary myelofibrosis. This confirms a diagnosis of a myeloproliferative neoplasm and helps your doctor determine the best treatment approach. While this is a chronic condition, it can be effectively managed with proper medical care and monitoring.
What does a negative JAK2 V617F mutation mean?
A negative result means this specific mutation was not detected, but it doesn't completely rule out a myeloproliferative disorder. Some people with these conditions have different genetic mutations or no detectable mutation at all. Your doctor may recommend additional genetic testing or use other clinical criteria to make a diagnosis and determine the best course of action.
What causes the JAK2 V617F mutation?
The JAK2 V617F mutation is an acquired genetic change that happens in your bone marrow cells during your lifetime, not something you're born with or inherit from your parents. It occurs spontaneously when a single DNA base pair changes in the JAK2 gene, causing the protein to become constantly active and leading to overproduction of blood cells. The exact reason why this mutation occurs is not fully understood.
How often should I retest if I have a myeloproliferative disorder?
If you've been diagnosed with a myeloproliferative disorder, you typically don't need to repeat the JAK2 mutation test since it's a one-time diagnostic test. However, you'll need regular blood count monitoring, usually every 3-6 months or more frequently depending on your treatment and condition. Your hematologist will create a personalized monitoring schedule to track your blood cells and adjust treatment as needed.
What should I do if my JAK2 mutation test is positive?
If your test is positive, you should work closely with a hematologist who specializes in blood disorders. Treatment may include medications to reduce blood cell counts, low-dose aspirin to prevent clots, or phlebotomy to remove excess blood. Lifestyle changes like staying well-hydrated, avoiding smoking, and managing cardiovascular risk factors are also important. Regular monitoring helps ensure your condition is well-controlled and reduces the risk of complications.
How’s this work?
Long story short:
- In the test options, use the filters or search box to narrow your choices and find the test you want.
- If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
- Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
- If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
- When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
- Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
- You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.
There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.
Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.
This policy applies to all insurance companies, including federal health insurance programs like Medicare.
If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
We get it – sometimes your needs change.
As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.
If you have any further questions, please text us at 754-799-7833 or email [email protected].
You can read more about our cancellation policy here.
How can I find a lab location near me?
Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.
If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
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Demo results
JAK2 V617F Mutation
Not Detected
Demo results
Not Detected
Detected
Not Detected
What this means
Your test came back negative, meaning the JAK2 V617F mutation was not detected in your blood sample. This is the expected result for most people and may help rule out certain myeloproliferative disorders, though your doctor may recommend additional testing if symptoms persist.
Recommended actions
Continue monitoring your blood counts with regular check-ups as recommended by your doctor
Discuss any persistent symptoms like fatigue, headaches, or unusual blood work findings with your healthcare provider
Consider additional genetic testing if your doctor suspects other mutations may be present
Maintain healthy lifestyle habits including regular exercise and a balanced diet to support overall blood health
* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
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Blood Test for Abnormal Blood Cell Growth and Blood Disorders
- Detects a specific gene mutation.
- Checks for blood disorder signs.
- Identifies abnormal cell growth indicators.
$2098
Example results
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