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IBD differentiation panel helps diagnose Crohn's disease and ulcerative colitis causes

Blood Test for Stomach Pain and Digestive Issues

Inflammatory Bowel Disease Differentiation Panel

Google
3,138 reviews
  • Pinpoint the cause of your gut issues
  • Clarify why you're experiencing stomach pain
  • Reveal hidden factors behind your digestive problems
First results as soon as overnight*

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you're experiencing chronic digestive symptoms like persistent abdominal pain, bloody diarrhea, unexplained weight loss, or severe cramping that interferes with daily life. It helps doctors differentiate between ulcerative colitis and Crohn's disease, two types of inflammatory bowel disease that require different treatment approaches. Many people use this test when standard treatments haven't worked or when doctors need to pinpoint the exact cause of ongoing gut inflammation.

How should I prepare for this test?

No special preparation is typically required for this test. You can take your regular medications and eat normally before your blood draw. However, if you're taking immunosuppressive medications or have recently started new IBD treatments, let your doctor know as these may affect antibody levels.

What's included in this test?

ANCA Screen with Reflex to ANCA Titer Myeloperoxidase Antibody (MPO) Proteinase-3 Antibody Saccharomyces cerevisiae Antibodies (ASCA) (IgA) Saccharomyces cerevisiae Antibodies (ASCA) (IgG)

This panel measures ANCA (antineutrophil cytoplasmic antibodies) with reflex to titer, Myeloperoxidase Antibody (MPO), Proteinase-3 Antibody, and Saccharomyces cerevisiae Antibodies (ASCA) in both IgA and IgG forms. These specific antibodies create a distinctive pattern that helps doctors differentiate between ulcerative colitis and Crohn's disease, as each condition typically produces different antibody combinations. ANCA and MPO are more commonly elevated in ulcerative colitis, while ASCA antibodies are more frequently found in Crohn's disease, giving your healthcare provider crucial information for accurate diagnosis and targeted treatment.

What happens after I get my results?
You'll receive detailed doctor notes in plain language explaining what your antibody patterns mean for diagnosing ulcerative colitis versus Crohn's disease. These notes provide specific guidance on next steps, which specialists to consult, and what treatment approaches may be most effective based on your results. Along with the standard lab report, you can track these markers over time using our trends feature to monitor disease progression or response to treatment.
When will I get my results?
Results are typically available within 3-5 business days after your blood sample reaches the laboratory. Complex antibody testing like ANCA with reflex to titer may occasionally take slightly longer if additional confirmation testing is needed. You'll be notified as soon as your complete results are ready to view.
Who should consider getting this test?
This test is valuable for anyone experiencing chronic or recurring digestive symptoms that suggest inflammatory bowel disease, especially if imaging or colonoscopy findings are inconclusive. It's particularly helpful when doctors need to distinguish between ulcerative colitis and Crohn's disease to guide treatment decisions. People with a family history of IBD or those not responding well to initial treatments may also benefit from this diagnostic panel.
What symptoms indicate I may need this test?
Key symptoms include persistent bloody diarrhea lasting more than a few weeks, severe abdominal cramping that doesn't go away, chronic fatigue combined with digestive issues, and unexplained weight loss despite eating normally. Other signs include urgent bowel movements that wake you at night, visible blood or mucus in stool, and persistent pain in the lower abdomen. If you're experiencing multiple symptoms that interfere with daily activities, this test can help identify the underlying cause.
What is the difference between ulcerative colitis and Crohn's disease?
Ulcerative colitis causes continuous inflammation limited to the innermost lining of the colon and rectum, typically starting at the rectum and spreading upward. Crohn's disease can affect any part of the digestive tract from mouth to anus with patchy, skip areas, and inflammation goes deeper through all layers of the intestinal wall. While both cause similar symptoms like diarrhea and abdominal pain, they require different treatment approaches, which is why distinguishing between them is so important.
How can I naturally support my digestive health with IBD?
Focus on identifying and avoiding trigger foods through an elimination diet, with common culprits including dairy, high-fiber raw vegetables during flares, and spicy foods. Eating smaller, more frequent meals and staying well-hydrated can reduce digestive stress. Stress management through meditation, gentle yoga, or counseling is crucial since stress often triggers flares. Adequate sleep and avoiding NSAIDs like ibuprofen, which can worsen inflammation, also help manage symptoms.
What happens if my results are abnormal?
Abnormal results showing elevated antibodies will help your doctor determine which type of IBD you likely have and develop an appropriate treatment plan. Your gastroenterologist may recommend additional tests like colonoscopy, imaging studies, or stool tests to confirm the diagnosis and assess disease severity. Treatment typically involves medications to reduce inflammation, dietary modifications, and regular monitoring. Early diagnosis and treatment are important to prevent complications and improve your quality of life.
How often should I retest these markers?
These antibody markers are typically used for initial diagnosis rather than ongoing monitoring, as they tend to remain relatively stable over time. Once diagnosed, your doctor will likely use other tests like inflammatory markers (CRP, fecal calprotectin) or imaging to monitor disease activity and treatment response. However, retesting may be recommended if your diagnosis is uncertain, symptoms change significantly, or your doctor is reconsidering the initial diagnosis.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
ANCA (Antineutrophil Cytoplasmic Antibodies) Positive
Demo results
Negative Positive
Positive

What this means

Your ANCA test came back positive, which is commonly associated with ulcerative colitis rather than Crohn's disease. This antibody pattern, especially when combined with other markers in this panel, helps your doctor determine the specific type of inflammatory bowel disease and choose the most effective treatment approach.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Blood Test for Stomach Pain and Digestive Issues

Google
3,138 reviews
  • Pinpoint the cause of your gut issues
  • Clarify why you're experiencing stomach pain
  • Reveal hidden factors behind your digestive problems

1,000,000+ blood tests later, here's what our customers say

Google reviews 3138 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.