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Autoimmune and connective tissue disorder testing for blistering diseases and vasculitis diagnosis

Antibody Test for Skin Blistering and Autoimmune Conditions

IgG, IgA, Indirect Immunofluorescence

Google
3,138 reviews
  • Pinpoint the cause of your digestive issues
  • Reveal hidden food sensitivities effortlessly
  • Clarify your immune system's response accurately
First results as soon as overnight*

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We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you're experiencing unexplained skin blistering, rashes that don't heal, or symptoms that suggest autoimmune conditions affecting your skin and connective tissues. It helps identify antibodies related to autoimmune blistering diseases, connective tissue disorders, and vasculitides that may be causing persistent skin problems or systemic symptoms. Many people use this test when standard skin treatments haven't worked and doctors suspect an underlying autoimmune process.

How should I prepare for this test?

No special preparation is typically required for this blood test. You can eat and drink normally before your appointment and continue taking your regular medications unless your doctor specifically instructs otherwise. It's helpful to inform the lab if you're currently on immunosuppressive medications or have recently received treatments that might affect antibody levels, as this context can help with result interpretation.

What's included in this test?

IgG, IgA, Indirect Immunofluorescence

This specialized test uses indirect immunofluorescence to detect circulating antibodies in your blood, including anti-epithelial cell surface antibodies, anti-basement membrane antibodies, anti-nuclear antibodies, and antineutrophil cytoplasmic antibodies. These antibodies are markers for autoimmune blistering diseases like pemphigus and bullous pemphigoid, connective tissue disorders like lupus and scleroderma, and various types of vasculitis. Together, these measurements help diagnose and monitor autoimmune conditions that affect your skin, blood vessels, and connective tissues.

What happens after I get my results?
You'll receive detailed doctor notes in simple language explaining what your antibody levels mean and whether they indicate an autoimmune blistering disease or connective tissue disorder. These notes include specific next steps like whether you need to see a dermatologist or rheumatologist, potential treatment options, and lifestyle adjustments. You'll also get the standard lab report and can track your antibody levels over time using our trends feature, which is especially helpful for monitoring disease activity or treatment response.
When will I get my results?
Results for indirect immunofluorescence testing typically take 5-7 business days as this is a specialized laboratory technique that requires careful analysis by trained technicians. You'll receive an email notification as soon as your results are ready to view in your secure online account. The complexity of the testing process ensures accurate detection and measurement of the various antibody patterns.
Who should consider getting this test?
This test is recommended for people with unexplained skin blistering, persistent rashes, or symptoms suggesting autoimmune disease such as joint pain, fatigue, or organ involvement. It's particularly important if you have a family history of autoimmune conditions, are experiencing symptoms that haven't responded to standard treatments, or your dermatologist or rheumatologist suspects an autoimmune blistering disease or connective tissue disorder.
What symptoms indicate I may need this test?
Common symptoms include painful blisters or sores on your skin or mucous membranes that don't heal normally, widespread rashes, mouth ulcers, sensitivity to sunlight, joint pain and swelling, or persistent fatigue. You might also experience skin that feels tight or thick, red or purple spots on your skin, or blisters that appear after minor friction or pressure.
What are autoimmune blistering diseases?
Autoimmune blistering diseases occur when your immune system mistakenly attacks proteins that hold skin layers together, causing painful blisters and sores. Common types include pemphigus, where blisters form within the skin layers, and bullous pemphigoid, where blisters form between skin layers. These conditions require proper diagnosis through antibody testing because they need specific treatments different from regular skin conditions.
What does a positive result mean?
A positive result means that specific antibodies were detected in your blood, indicating your immune system is producing antibodies against your own tissues. The specific pattern and type of antibodies help identify which autoimmune condition you may have, such as pemphigus, lupus, or vasculitis. Your doctor will correlate these findings with your symptoms to confirm a diagnosis and develop an appropriate treatment plan.
How often should I retest if I have an autoimmune condition?
If you're diagnosed with an autoimmune blistering disease or connective tissue disorder, your doctor will typically monitor antibody levels every 3-6 months during active disease or treatment adjustments. Once your condition is stable on treatment, testing may be reduced to every 6-12 months. Regular monitoring helps track disease activity and treatment effectiveness, allowing for timely adjustments to your care plan.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Anti-Epithelial Cell Surface Antibodies (IgG) Negative
Demo results
Negative Positive
Negative

What this means

Your test came back negative, meaning no anti-epithelial cell surface antibodies were detected in your blood. This is the expected and healthy result, suggesting no active autoimmune blistering disease affecting the connections between skin cells.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
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Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Antibody Test for Skin Blistering and Autoimmune Conditions

Google
3,138 reviews
  • Pinpoint the cause of your digestive issues
  • Reveal hidden food sensitivities effortlessly
  • Clarify your immune system's response accurately

1,000,000+ blood tests later, here's what our customers say

Google reviews 3138 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.