What happens after I get my results?

You'll receive detailed doctor notes in simple language explaining what your HLA DRB1 type means for your immune system and potential autoimmune risks. These notes include personalized recommendations about which autoimmune conditions you may be predisposed to and whether further genetic counseling or specialist consultation would be beneficial. You'll also get the standard lab report and can keep this genetic information on file for future transplant matching needs or family health planning.

When will I get my results?

Genetic testing typically takes longer than standard blood work because it involves specialized laboratory analysis of your DNA. You can generally expect your HLA DRB1 results within 1-2 weeks. This test provides permanent genetic information that doesn't change over time, so you won't need to retest unless required for updated transplant matching protocols.

Who should consider getting this test?

This test is important for anyone being evaluated as a potential organ or bone marrow donor, people with unexplained autoimmune symptoms seeking a diagnosis, or those with strong family histories of autoimmune diseases. It's also valuable for individuals from ethnic backgrounds with higher rates of certain autoimmune conditions, or anyone wanting to understand their genetic risk factors for immune-related disorders.

What symptoms indicate I may need this test?

Consider this test if you're experiencing persistent joint pain and stiffness, unexplained chronic fatigue, recurrent digestive issues like bloating or diarrhea, or skin rashes that don't respond to treatment. Other signs include frequent infections, unexplained weight changes, or multiple family members with autoimmune conditions. These symptoms may indicate an autoimmune process where your HLA type could provide diagnostic clarity.

What is HLA DRB1 and why does it matter?

HLA DRB1 is a gene that creates proteins on the surface of your cells, acting like a security badge that helps your immune system recognize what belongs in your body and what doesn't. Certain variants of this gene are strongly linked to autoimmune diseases where the immune system mistakenly attacks healthy tissue. Knowing your HLA DRB1 type helps doctors assess your risk for specific autoimmune conditions and can guide early monitoring or preventive strategies.

What does my HLA type mean for autoimmune risk?

Certain HLA DRB1 variants are associated with increased risk for specific autoimmune diseases, but having a risk variant doesn't mean you'll definitely develop the condition. For example, HLA-DRB1*04 is linked to rheumatoid arthritis, while DRB1*03 is associated with type 1 diabetes and celiac disease. Environmental factors, lifestyle, and other genes also play important roles, so this test provides risk information rather than a definitive diagnosis.

How is this test used for transplant matching?

For organ and bone marrow transplants, matching HLA types between donor and recipient is crucial for preventing rejection. The closer the HLA match, the better your immune system will accept the transplanted tissue as belonging to your body. This test is essential for evaluating potential living donors within families and is routinely performed before transplant procedures to find the best possible match and improve long-term transplant success.