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HLA genetic testing for immune system function and autoimmune disease risk assessment

HLA Genetic Test for Immune System and Autoimmune Risk

HLA A,B,C Low Resolution

Google
3,141 reviews
  • Pinpoint genetic factors affecting your immune system
  • Reveal potential risks for autoimmune diseases
  • Clarify your body's response to infections
First results as soon as overnight*

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you're experiencing unexplained autoimmune symptoms, have a family history of conditions like celiac disease or rheumatoid arthritis, or need genetic typing for organ transplantation. It identifies specific genetic markers that influence how your immune system recognizes your own cells versus foreign substances, helping explain why you might be more susceptible to certain infections or autoimmune conditions. Many people use this test to understand their genetic predisposition to immune-related diseases or when preparing for transplant procedures.

What's included in this test?

HLA A,B,C Low Resolution

This test analyzes your HLA-A, HLA-B, and HLA-C genes at low resolution, which are the main genetic markers that determine how your immune system identifies cells and responds to threats. These specific genes play crucial roles in organ transplant compatibility, susceptibility to autoimmune diseases like celiac disease and type 1 diabetes, and how effectively your body fights certain infections. Together, these measurements provide important insights into your inherited immune characteristics and potential health risks.

What happens after I get my results?

You'll receive detailed doctor notes in simple language explaining what your HLA genetic profile means for your immune system function and disease risk. These notes include personalized recommendations about which autoimmune conditions to monitor, lifestyle strategies to support immune health, and whether genetic counseling or specialist follow-up would be beneficial. You'll also get the standard lab report with your specific HLA genetic markers, which can be valuable for future medical decisions including transplant compatibility.

Who should consider getting this test?
This test is important for anyone with a family history of autoimmune diseases, people experiencing unexplained symptoms that suggest immune dysfunction, or individuals preparing for organ or bone marrow transplantation. It's also valuable for those with recurrent infections, suspected celiac disease, or anyone wanting to understand their genetic predisposition to immune-related conditions. Ethnic background can influence HLA patterns, so it's particularly useful for understanding inherited risks.
What symptoms indicate I may need this test?
Consider this test if you experience chronic fatigue, joint pain or swelling, persistent digestive issues, recurrent infections, unexplained skin rashes, or other signs of immune system dysfunction. It's also relevant if you have multiple family members with autoimmune conditions, experience adverse drug reactions (particularly to certain medications), or have symptoms suggestive of conditions like celiac disease, psoriasis, or ankylosing spondylitis that have strong HLA associations.
What are HLA genes and why do they matter?
HLA (Human Leukocyte Antigen) genes are inherited genetic markers on your cells that act like identification badges, helping your immune system distinguish between your own cells and foreign invaders. These genes determine transplant compatibility, influence your susceptibility to over 100 autoimmune diseases, and affect how your body responds to infections and vaccines. Understanding your HLA type provides valuable insights into your personalized health risks and can guide preventive care strategies.
How can I support my immune system with autoimmune risk?
Focus on an anti-inflammatory diet rich in omega-3 fatty acids, colorful vegetables, and whole foods while limiting processed foods and excess sugar. Prioritize 7-9 hours of quality sleep, manage stress through meditation or yoga, and engage in moderate exercise without overtraining. Maintain gut health with fermented foods and probiotics, avoid smoking, limit alcohol, and work with healthcare providers to identify and address any nutritional deficiencies or food sensitivities that may trigger immune responses.
What does my HLA type mean for autoimmune disease risk?
Certain HLA types are strongly associated with specific autoimmune conditions—for example, HLA-B27 with ankylosing spondylitis, or certain HLA types with celiac disease and type 1 diabetes. However, having a high-risk HLA type doesn't mean you'll definitely develop the condition; it simply means your genetic susceptibility is higher. Environmental factors, lifestyle, and other genes also play important roles, so this information helps guide monitoring and prevention strategies rather than predict certainty.
Can HLA typing help with transplant matching?
Yes, HLA typing is essential for organ and bone marrow transplantation because it determines compatibility between donor and recipient. The closer the HLA match, the lower the risk of organ rejection or graft-versus-host disease. This test identifies your specific HLA profile, which can be compared with potential donors—often family members—to find the best match and improve transplant outcomes.
What should I do with my HLA results?
Share your results with your primary care doctor and any specialists managing autoimmune or immune-related conditions. If you have high-risk HLA markers for specific diseases, discuss appropriate screening schedules and preventive strategies. Keep a copy of your HLA results in your permanent medical records, as this information remains relevant throughout your life for transplant considerations, medication selection, and understanding disease susceptibility. Consider genetic counseling if you have concerns about family planning or inherited risks.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
HLA-B27 Genetic Marker Negative
Demo results
Negative Positive
Negative

What this means

Your HLA-B27 test came back negative, meaning you do not carry this particular genetic marker associated with certain autoimmune conditions like ankylosing spondylitis. This is the most common result and significantly lowers your genetic risk for B27-associated inflammatory diseases.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

HLA Genetic Test for Immune System and Autoimmune Risk

Google
3,141 reviews
  • Pinpoint genetic factors affecting your immune system
  • Reveal potential risks for autoimmune diseases
  • Clarify your body's response to infections

1,000,000+ blood tests later, here's what our customers say

Google reviews 3141 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.