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Plasma histamine test for people experiencing unexplained allergic reactions and symptoms

Blood Test for Allergic Reactions and Hives

Histamine, Plasma

Google
3,138 reviews
  • Checks allergy-related histamine levels
  • Measures body's allergic reaction response
  • Evaluates histamine for allergy diagnosis
First results as soon as overnight*

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you're experiencing unexplained allergic reactions like itching, hives, flushing, or even fainting episodes. It measures histamine levels in your blood to help identify if your body is having an excessive allergic response or other conditions that cause histamine release. Many people use this test when they have severe allergic symptoms that haven't been explained by standard allergy testing.

How should I prepare for this test?

You'll need to avoid taking allergy medications, antihistamines, oral corticosteroids, and substances that block H2 receptors for 24 hours before your blood draw. This includes common allergy medicines like Benadryl, Claritin, Zyrtec, and heartburn medications like Pepcid or Zantac. Taking these medications can affect your histamine levels and make your results inaccurate, so proper preparation is important for meaningful results.

What's included in this test?

Histamine, Plasma

This test measures plasma histamine, which is a chemical your body releases during allergic reactions. Elevated histamine levels can explain symptoms like itching, flushing, hives, digestive issues, and in severe cases, fainting or shock. This measurement helps identify whether your symptoms are truly related to excessive histamine release and can also help detect certain rare conditions like gastric carcinoid tumors.

What happens after I get my results?
You'll receive detailed doctor notes in simple language explaining what your histamine levels mean for your allergic reactions and overall health. These notes include personalized recommendations like dietary changes to avoid histamine-rich foods, potential medication adjustments, or whether you should see an allergist for further evaluation. You'll also get the standard lab report and can track your histamine levels over time using our trends feature to see how interventions are working.
Who should consider getting this test?
This test is useful for people experiencing severe or unexplained allergic symptoms like chronic hives, flushing, or episodes of fainting. It's also helpful if you have symptoms that suggest mast cell disorders or if standard allergy testing hasn't identified the cause of your reactions. People with suspected gastric carcinoid tumors may also benefit from this test.
What symptoms indicate I may need this test?
Common symptoms that suggest you might need this test include frequent or unexplained hives, persistent itching without visible rash, facial flushing or skin redness, digestive issues like vomiting or diarrhea during reactions, episodes of low blood pressure or fainting, and severe allergic reactions that don't respond well to typical allergy treatments.
How can I naturally manage histamine levels?
Following a low-histamine diet can help by avoiding aged cheeses, fermented foods, alcohol, processed meats, and certain fish. Fresh foods are generally lower in histamine than leftovers or aged items. Managing stress through relaxation techniques, getting adequate sleep, and supporting gut health with probiotics may also help regulate histamine response. Some people find natural antihistamines like quercetin or vitamin C helpful.
What is histamine and why does it matter?
Histamine is a chemical your immune system releases during allergic reactions to help your body fight off what it perceives as threats. While histamine is essential for immune function, too much can cause uncomfortable symptoms like itching, swelling, hives, digestive issues, and in severe cases, dangerous reactions like shock. Understanding your histamine levels helps identify if your symptoms are truly allergy-related or caused by other conditions.
What does high histamine mean?
High histamine levels typically indicate an active allergic reaction or excessive histamine release in your body. This can occur during acute allergic responses, with certain mast cell disorders, or rarely with gastric carcinoid tumors. Elevated histamine explains symptoms like hives, flushing, itching, digestive upset, and in severe cases, low blood pressure or fainting spells.
How often should I retest histamine levels?
Retesting frequency depends on your specific situation and symptoms. If you're being evaluated for a suspected histamine-related disorder, your doctor may retest during active symptoms versus when you're symptom-free. If you're monitoring treatment effectiveness, retesting every 3-6 months may be appropriate. For ongoing conditions, your healthcare provider will determine the best monitoring schedule based on your response to treatment.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Histamine, Plasma 12.5 ng/mL
Demo results
Low Optimal 0.0 - 10.0 High
12.5 ng/mL

What this means

Your plasma histamine level is elevated above the optimal range, which may indicate an active allergic response or excessive histamine release in your body. This elevation could explain symptoms like hives, flushing, itching, or digestive issues you may be experiencing.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Blood Test for Allergic Reactions and Hives

Google
3,138 reviews
  • Checks allergy-related histamine levels
  • Measures body's allergic reaction response
  • Evaluates histamine for allergy diagnosis

1,000,000+ blood tests later, here's what our customers say

Google reviews 3138 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.