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Aspirin resistance test for individuals managing cardiovascular disease and blood clot risk

Blood Test for Aspirin Effectiveness and Heart Health

AspirinWorks® 11-Dehydrothromboxane B2 (11-dhTXB2) with Creatinine

Google
3,138 reviews
  • Pinpoint your risk of blood clots
  • Assess how well aspirin is working
  • Reveal hidden cardiovascular issues
First results as soon as overnight*

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you're taking aspirin to prevent heart attacks or strokes and want to know if it's actually working for you. Some people are aspirin-resistant, meaning their bodies don't respond to aspirin's blood-thinning effects as expected. This test helps identify whether you're getting the cardiovascular protection you need from your aspirin therapy, which is especially important if you have heart disease, have had a previous heart event, or are at high risk for blood clots.

How should I prepare for this test?

Since this is a urine test, no special fasting is required. However, it's important to continue taking your aspirin as prescribed before testing, as the purpose is to measure how well aspirin is working in your body. Your doctor may provide specific instructions about timing, such as collecting urine at a certain time of day or after a specific duration of aspirin use. Follow any personalized guidance from your healthcare provider for the most accurate results.

What's included in this test?

AspirinWorks® 11-Dehydrothromboxane B2 (11-dhTXB2) with Creatinine

This test measures 11-dehydrothromboxane B2 (11-dhTXB2) with creatinine in your urine. 11-dhTXB2 is the principal metabolite of thromboxane B2, which platelets produce when they form clots. By measuring this substance, the test reveals whether aspirin is successfully blocking platelet activity and reducing your clotting risk. The creatinine measurement helps normalize the results for accurate interpretation, giving your doctor clear insight into your body's response to aspirin therapy.

What happens after I get my results?
You'll receive detailed doctor notes in simple language explaining whether your aspirin therapy is effectively reducing your blood clotting risk. These notes include personalized recommendations such as whether your current aspirin dose is appropriate, if alternative antiplatelet medications should be considered, or if lifestyle factors may be affecting aspirin's effectiveness. You'll also get the standard lab report and can track your 11-dhTXB2 levels over time using our trends feature, which is especially helpful if your doctor adjusts your treatment plan.
Who should consider getting this test?
This test is important for anyone taking aspirin to prevent heart attacks or strokes, especially if you have coronary artery disease, have had a previous heart attack or stroke, or have been diagnosed with cardiovascular disease. It's also valuable if you're starting aspirin therapy and want to confirm it's working, or if you've had clotting events despite taking aspirin regularly. People with a family history of aspirin resistance or those who haven't seen expected benefits from aspirin therapy should also consider this test.
What symptoms indicate I may need this test?
Consider this test if you're experiencing chest pain, shortness of breath, or other cardiovascular symptoms despite taking aspirin regularly. It's also important if you've had unexplained blood clots, mini-strokes (TIAs), or heart-related events while on aspirin therapy. Even without new symptoms, if you have cardiovascular disease and are taking aspirin for prevention, this test helps confirm your medication is providing the protection you need.
What is aspirin resistance and why does it matter?
Aspirin resistance occurs when your body doesn't respond properly to aspirin's blood-thinning effects, meaning your platelets continue to form clots despite taking the medication. This matters because if aspirin isn't working, you may not be getting the cardiovascular protection you need to prevent heart attacks and strokes. Identifying aspirin resistance allows your doctor to adjust your treatment plan, potentially changing your dose, adding another medication, or switching to alternative antiplatelet therapies to ensure you're adequately protected.
What does high 11-dhTXB2 mean?
High levels of 11-dhTXB2 in your urine suggest that your platelets are still producing significant amounts of thromboxane, which means aspirin is not effectively blocking platelet activity. This indicates possible aspirin resistance, meaning you may not be getting adequate protection against blood clots. High results warrant a conversation with your doctor about adjusting your treatment plan, which might include increasing your aspirin dose, adding another medication, or switching to a different antiplatelet therapy.
What causes aspirin resistance?
Aspirin resistance can be caused by genetic factors that affect how your body metabolizes aspirin or how your platelets function. Other causes include taking aspirin inconsistently, drug interactions with NSAIDs like ibuprofen that compete with aspirin, poor absorption due to certain coatings on aspirin tablets, or medical conditions that increase platelet production. Sometimes lifestyle factors like smoking, obesity, or high cholesterol can also reduce aspirin's effectiveness. Understanding the cause helps your doctor optimize your treatment approach.
How often should I retest my aspirin effectiveness?
If your initial test shows aspirin is working well, you may only need annual testing or when your cardiovascular condition changes. However, if results show aspirin resistance and your doctor adjusts your treatment, retesting in 4-8 weeks after changes is important to confirm the new approach is effective. You should also consider retesting if you start new medications that might interact with aspirin, experience new cardiovascular symptoms, or have changes in your overall health status that could affect aspirin's effectiveness.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

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Demo results
11-Dehydrothromboxane B2 (11-dhTXB2) 1850 pg/mg creatinine
Demo results
Optimal < 1500 High ≥ 1500
1850 pg/mg creatinine

What this means

Your 11-dhTXB2 level is elevated, suggesting that aspirin may not be fully blocking platelet activity in your body. This indicates possible aspirin resistance, meaning you might not be getting the full cardiovascular protection expected from your aspirin therapy. This finding is important to discuss with your doctor to optimize your treatment plan.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
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Blood Test for Aspirin Effectiveness and Heart Health

Google
3,138 reviews
  • Pinpoint your risk of blood clots
  • Assess how well aspirin is working
  • Reveal hidden cardiovascular issues

1,000,000+ blood tests later, here's what our customers say

Google reviews 3138 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.