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Anti-CCP3 test for early rheumatoid arthritis detection and joint health monitoring

Blood Test for Joint Pain and Arthritis Symptoms

Anti-Cyclic Citrullinated Peptide 3 (Anti-CCP3) IgG

Google
3,138 reviews
  • Highly specific for rheumatoid arthritis
  • Predicts joint damage and progression
  • Used in early diagnosis of RA
First results as soon as overnight*

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you're experiencing persistent joint pain, stiffness (especially in the morning), swelling in multiple joints, or if you have a family history of rheumatoid arthritis. It helps detect RA at an early stage before significant joint damage occurs, which is crucial for starting treatment early. Many people use this test when they have unexplained joint symptoms or want to confirm if their arthritis is rheumatoid in nature.

What's included in this test?

Cyclic Citrullinated Peptide (CCP) Antibody (IgG)

This test measures Cyclic Citrullinated Peptide (CCP) Antibody IgG levels, which are highly specific markers for rheumatoid arthritis. When present, these antibodies indicate your immune system is attacking your joint tissues, helping distinguish rheumatoid arthritis from other types of joint conditions. This measurement provides crucial diagnostic information and helps predict the severity and progression of RA.

What happens after I get my results?

You'll receive detailed doctor notes in simple language explaining what your Anti-CCP3 antibody levels mean for your joint health and RA risk. These notes include personalized recommendations like whether you should consult a rheumatologist, consider anti-inflammatory dietary changes, or discuss early treatment options. You'll also get the standard lab report and can track your antibody levels over time using our trends feature to monitor disease progression or treatment effectiveness.

Who should consider getting this test?
This test is important for anyone experiencing persistent joint pain, swelling, or morning stiffness lasting more than 30 minutes. It's particularly valuable if you have a family history of rheumatoid arthritis, have been diagnosed with another autoimmune condition, or your doctor suspects RA based on your symptoms. Early testing can lead to earlier treatment and better long-term outcomes.
What symptoms indicate I may need this test?
Common signs include joint pain and swelling in multiple joints (especially hands, wrists, and feet), prolonged morning stiffness lasting more than an hour, fatigue and low energy, and symmetrical joint involvement (same joints on both sides of your body). You may also notice decreased range of motion, joint warmth, or general feelings of being unwell.
What does a positive Anti-CCP3 result mean?
A positive result means CCP antibodies were detected in your blood, which strongly suggests rheumatoid arthritis. This doesn't mean you currently have severe disease, but it indicates your immune system is producing antibodies that attack joint tissue. Positive results, especially with high levels, are associated with more aggressive disease and greater risk of joint damage over time, making early treatment important.
What does a negative Anti-CCP3 result mean?
A negative result means no CCP antibodies were detected, which makes rheumatoid arthritis less likely but doesn't completely rule it out. About 20-30% of people with RA are seronegative, meaning they test negative for these antibodies. If you still have joint symptoms, your doctor may order additional tests or monitor your condition over time.
How can I naturally support my joint health?
Focus on an anti-inflammatory diet rich in omega-3 fatty acids from fish, walnuts, and flaxseeds, while reducing processed foods and sugar. Regular low-impact exercise like swimming, walking, or yoga helps maintain joint flexibility without causing damage. Managing stress through meditation or relaxation techniques, getting adequate sleep, and maintaining a healthy weight can all help reduce inflammation and protect your joints.
What is Anti-CCP and why does it matter?
Anti-CCP (Anti-Cyclic Citrullinated Peptide) antibodies are proteins your immune system produces when it mistakenly attacks the lining of your joints. These antibodies are highly specific to rheumatoid arthritis and can appear years before symptoms develop. Testing for Anti-CCP helps doctors diagnose RA early, predict disease severity, and distinguish it from other forms of arthritis.
How often should I retest my Anti-CCP levels?
If your initial test is positive, your doctor will likely monitor your condition through other markers and symptoms rather than frequent Anti-CCP retesting, as these antibody levels tend to remain stable over time. If your test is negative but symptoms persist, retesting in 6-12 months may be recommended. Once diagnosed and on treatment, your rheumatologist will determine appropriate monitoring schedules based on your individual case.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
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No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
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Demo results
Anti-CCP Antibody Negative
Demo results
Negative Positive
Negative

What this means

Your test came back negative, meaning no Anti-CCP antibodies were detected in your blood. This makes rheumatoid arthritis less likely, though it doesn't completely rule it out since some people with RA can be seronegative. This is a reassuring result.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
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Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Blood Test for Joint Pain and Arthritis Symptoms

Google
3,138 reviews
  • Highly specific for rheumatoid arthritis
  • Predicts joint damage and progression
  • Used in early diagnosis of RA

1,000,000+ blood tests later, here's what our customers say

Google reviews 3138 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.