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Alkaline phosphatase isoenzyme test for identifying liver and bone disorders

Blood Test for Liver and Bone Health Issues

Alkaline phosphatase isoenzymes

Google
3,138 reviews
  • Checks enzymes in your liver and bones
  • Helps find liver or bone issues
  • Measures specific body enzyme levels
First results as soon as overnight*

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

90 day happiness guarantee

We stand behind our service

Prescription & fees included

Go directly to the lab, no extra fees

Easy to understand results

With friendly doctor's notes & guidance

Fast & convenient

Lab visit as quick as 10 mins in & out

What's this test for?

This test is ideal if you've had blood work showing high alkaline phosphatase levels and your doctor needs to find out where it's coming from. Elevated alkaline phosphatase can signal liver problems, bone disorders, or other conditions, but this test pinpoints the specific source by identifying which organs are producing the enzyme. It helps guide your doctor toward the right diagnosis and treatment plan when something is causing your alkaline phosphatase to be abnormally high.

How should I prepare for this test?

No fasting is needed for this test, which makes it convenient and easy to schedule. You can eat and drink normally before your blood draw. However, it's always a good idea to inform your healthcare provider about any medications or supplements you're taking, as some can affect enzyme levels.

What's included in this test?

Alkaline Phosphatase Bone Isoenzymes Intestinal Isoenzymes Liver Isoenzymes Placental Isoenzymes

This test measures Alkaline Phosphatase along with its specific isoenzymes from bone, liver, intestine, and placenta. By identifying which tissue is producing elevated alkaline phosphatase, your doctor can distinguish between bone disorders like Paget's disease or fractures, liver conditions such as hepatitis or bile duct obstruction, intestinal issues, or pregnancy-related changes. This detailed breakdown provides crucial diagnostic information that a total alkaline phosphatase test alone cannot reveal.

What happens after I get my results?
You'll receive doctor notes in simple language explaining which isoenzyme types were elevated and what that means for your liver, bone, or other organ health. These notes include personalized recommendations about which specialist to see, what additional tests might be needed, and lifestyle factors to consider based on your results. You'll also get the standard lab report and can track your isoenzyme levels over time using our trends feature, which is especially helpful for monitoring chronic liver or bone conditions.
Who should consider getting this test?
This test is recommended for anyone whose routine blood work has shown elevated alkaline phosphatase levels. It's particularly useful for people experiencing unexplained bone pain, liver symptoms like jaundice or abdominal discomfort, or those with known bone or liver conditions that need monitoring. Your doctor may order this test to differentiate between liver disease, bone disorders, or other causes of elevated alkaline phosphatase.
What symptoms indicate I may need this test?
You may need this test if you're experiencing symptoms like persistent bone pain, unexplained fractures, yellowing of the skin or eyes, abdominal pain, fatigue, or abnormal liver function. It's also indicated if routine blood work shows high alkaline phosphatase without a clear cause. This test helps your doctor determine whether your symptoms are related to liver, bone, or other organ issues.
What is alkaline phosphatase and why does it matter?
Alkaline phosphatase is an enzyme found in several body tissues, including liver, bones, intestines, and kidneys. When your total alkaline phosphatase is high, it signals that something may be wrong, but doesn't tell you where the problem is. The isoenzyme test breaks down the total into specific types from different organs, allowing your doctor to pinpoint whether the elevation is coming from your liver, bones, or elsewhere, which is crucial for proper diagnosis and treatment.
What does high bone isoenzyme mean?
High bone isoenzyme levels indicate increased bone activity, which can occur with bone growth in children and adolescents, bone healing after fractures, or bone diseases like Paget's disease, osteomalacia, or bone metastases. If you're an adult with elevated bone isoenzymes, your doctor will likely investigate further to rule out bone disorders or abnormal bone remodeling. This helps distinguish bone-related causes from liver problems when total alkaline phosphatase is elevated.
What does high liver isoenzyme mean?
Elevated liver isoenzyme suggests a liver or bile duct problem, such as hepatitis, cirrhosis, bile duct obstruction, or fatty liver disease. This finding helps your doctor focus on your liver health and may prompt additional liver function tests or imaging studies. High liver isoenzyme levels can also occur with certain medications or alcohol use, so your doctor will consider your complete medical history when interpreting results.
How often should I retest my alkaline phosphatase isoenzymes?
Retesting frequency depends on your diagnosis and treatment plan. If you're being monitored for a known liver or bone condition, your doctor may order this test every few months to track disease progression or treatment response. For one-time diagnostic purposes to identify the source of elevated alkaline phosphatase, you may not need retesting once the cause is identified and addressed. Your healthcare provider will determine the appropriate follow-up schedule based on your specific situation.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.

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Demo results
Liver Isoenzymes 65 U/L
Demo results
Low Optimal 20 - 50 High
65 U/L

What this means

Your liver isoenzyme levels are elevated above the optimal range, which suggests increased liver activity or possible liver stress. This could be related to liver inflammation, bile duct issues, fatty liver, or certain medications. While not necessarily alarming, it warrants attention and may benefit from lifestyle modifications or further evaluation.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.
Here’s how easy it is to get blood work done on your terms
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Blood Test for Liver and Bone Health Issues

Google
3,138 reviews
  • Checks enzymes in your liver and bones
  • Helps find liver or bone issues
  • Measures specific body enzyme levels

1,000,000+ blood tests later, here's what our customers say

Google reviews 3138 reviews Next
Still got questions? Text our super-cool support team at 754-799-7833 to get help finding your ideal checkup.