Understanding Lab Tests for Zollinger-Ellison Syndrome
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Zollinger-Ellison Syndrome (ZES) is a rare disorder caused by gastrin-producing tumors called gastrinomas, typically located in the pancreas or duodenum. These tumors secrete excessive amounts of gastrin hormone, leading to overproduction of stomach acid and the development of severe, recurrent peptic ulcers.
Recommended Test
Gastrin
This blood test measures gastrin hormone levels and is the primary diagnostic tool for Zollinger-Ellison Syndrome. Gastrinomas characteristic of this condition produce excessive amounts of gastrin, resulting in significantly elevated blood levels. High gastrin concentrations indicate the presence of these hormone-secreting tumors and help confirm the diagnosis of ZES.
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How Blood Tests Diagnose Zollinger-Ellison Syndrome
The key to diagnosing Zollinger-Ellison Syndrome lies in measuring gastrin levels in the blood. Since gastrinomas produce abnormally high amounts of this hormone, elevated gastrin levels serve as a primary diagnostic marker for this condition. This blood test is essential because the symptoms of ZES can mimic other digestive disorders.
Understanding Your Results
Significantly elevated gastrin levels, particularly when combined with symptoms like recurrent peptic ulcers, abdominal pain, and diarrhea, strongly suggest Zollinger-Ellison Syndrome. However, other conditions can also cause moderately elevated gastrin levels, so your healthcare provider may recommend additional testing or imaging studies to confirm the diagnosis and locate any tumors.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment of Zollinger-Ellison Syndrome.
