Von Willebrand Disease is an inherited bleeding disorder that affects how blood clots. It is caused by a deficiency or dysfunction of von Willebrand factor, a protein essential for platelet adhesion and clot formation. The Prothrombin Time and Partial Thromboplastin Time test is the most important initial screening test for diagnosing this genetic clotting disorder.
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Von Willebrand Disease is caused by genetic mutations that affect the production or function of von Willebrand factor, a blood protein critical for clotting. These mutations can be inherited from one or both parents in an autosomal dominant or recessive pattern. When von Willebrand factor is deficient or dysfunctional, platelets cannot stick together properly to form blood clots, leading to prolonged bleeding episodes after injuries, surgeries, dental procedures, or even spontaneously from mucous membranes.
The Prothrombin Time and Partial Thromboplastin Time test is the most important initial screening test for Von Willebrand Disease because it measures how long blood takes to clot. People with VWD typically show a prolonged PTT result because their deficient or dysfunctional von Willebrand factor prevents normal clot formation. While this test identifies clotting abnormalities, your doctor may order additional specialized tests like von Willebrand factor antigen, von Willebrand factor activity, and Factor VIII levels to confirm the diagnosis and determine the specific type and severity of the disease.
You should get tested if you experience frequent nosebleeds that are hard to stop, easy bruising without known injury, prolonged bleeding from cuts or after dental work, heavy menstrual periods lasting more than seven days, or if you have a family history of bleeding disorders. Testing is especially important before scheduled surgeries or dental procedures, as undiagnosed VWD can lead to dangerous bleeding complications. Women planning pregnancy should also consider testing since VWD can cause complications during childbirth.
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What this means
Your INR is slightly elevated above the typical therapeutic range for most conditions. This means your blood is taking longer to clot than ideal, which increases your risk of bleeding. While this may simply require a warfarin dosage adjustment, it's important to follow up with your healthcare provider to ensure safe anticoagulation.
Recommended actions
Contact your doctor or anticoagulation clinic promptly to discuss dosage adjustment
Avoid activities with high risk of injury or trauma until INR is stabilized
Be consistent with vitamin K intake (leafy greens) as fluctuations can affect INR
Retest INR within 3-7 days after any medication adjustment
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