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Vasculitis is a group of disorders characterized by inflammation of blood vessels including arteries, veins, and capillaries throughout the body. It is caused by an autoimmune response where the immune system attacks blood vessel walls, often triggered by infections, medications, or underlying autoimmune conditions. The Myeloperoxidase test is the most important test for vasculitis diagnosis because it measures enzyme levels produced by activated neutrophils during blood vessel inflammation.
Vasculitis is caused by an autoimmune response where your immune system mistakenly attacks your blood vessel walls, leading to inflammation and damage. This attack can be triggered by bacterial or viral infections like hepatitis B or C, certain medications including antibiotics and anti-seizure drugs, or underlying autoimmune diseases such as rheumatoid arthritis or lupus. In many cases, the exact trigger remains unknown, but the result is the same: inflamed blood vessels that can restrict blood flow and damage organs throughout your body.
The Myeloperoxidase test is the most important blood test for vasculitis because it measures levels of this enzyme released by neutrophils during active blood vessel inflammation. When your blood vessels are inflamed, neutrophils rush to the area and release myeloperoxidase, making elevated levels a key indicator of vasculitis activity. This test helps your doctor assess the severity of inflammation and monitor how well treatment is working. Additional tests like C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and antineutrophil cytoplasmic antibodies (ANCA) may be ordered alongside myeloperoxidase to provide a complete picture of your condition.
You should get tested if you experience unexplained skin rashes or purple spots, persistent fever with joint pain, numbness or weakness in your hands or feet, or sudden vision changes or eye pain. Testing is especially important if you notice blood in your urine, cough up blood, have difficulty breathing, or develop severe headaches that don't respond to typical pain relievers. Early diagnosis through blood testing can prevent serious organ damage and help your doctor start treatment before the condition worsens.
What this means
Your Myeloperoxidase levels are elevated above the optimal range, indicating active inflammation in your blood vessels. This suggests increased cardiovascular risk and potential immune system activity that may benefit from lifestyle interventions and closer monitoring to protect your heart health.
Recommended actions
Adopt an anti-inflammatory diet rich in omega-3 fatty acids from fish, walnuts, and berries
Incorporate regular moderate exercise like brisk walking or swimming 30 minutes daily
Manage stress through meditation, yoga, or other relaxation techniques
Retest in 3-6 months after implementing lifestyle changes to track improvement
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