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Thrombosis is the formation of a blood clot inside a blood vessel that obstructs blood flow and can lead to deep vein thrombosis, pulmonary embolism, heart attack, or stroke. It is caused by elevated levels of clotting proteins such as fibrinogen and lipoprotein (a), which promote excessive clot formation. The Fibrinogen Activity test is the most important test for thrombosis risk because it measures how quickly fibrinogen converts to fibrin, the protein that forms blood clots.
Thrombosis is caused by an imbalance in your body's clotting system, where proteins like fibrinogen and lipoprotein (a) become elevated and promote excessive blood clot formation inside your vessels. Specific triggers include prolonged immobility, injury to blood vessels, inherited clotting disorders, certain medications like birth control pills, pregnancy, cancer, and inflammatory conditions. When these clotting factors are too high or your blood flow is sluggish, clots can form and block circulation to vital organs, leading to potentially life-threatening complications like deep vein thrombosis, pulmonary embolism, stroke, or heart attack.
The Fibrinogen Activity test is the most important test for assessing thrombosis risk because it measures how quickly fibrinogen converts to fibrin, the actual protein that forms blood clots. This test detects elevated clotting activity that indicates you are prone to forming clots more rapidly and extensively than normal. The Lipoprotein (a) test is also essential because high levels of this lipid particle significantly increase your risk of venous thrombosis, including deep vein thrombosis and pulmonary embolism. Together, these tests identify the key biological factors that make your blood more likely to clot abnormally, allowing your doctor to recommend preventive treatments like anticoagulants before a dangerous clot forms.
You should get tested if you have a family history of blood clots or if close relatives experienced clots at a young age. Get tested if you are planning surgery or will be immobilized for extended periods, such as long flights or bed rest, since these situations dramatically increase clot risk. You should also consider testing if you have unexplained leg swelling, pain, or redness, if you are starting birth control pills or hormone therapy, or if you have had a previous clot and want to understand your ongoing risk. Early testing helps you and your doctor implement preventive strategies before a life-threatening clot develops.
What this means
Your fibrinogen level is elevated above the optimal range, which indicates increased inflammation in your body and higher cardiovascular risk. Elevated fibrinogen makes your blood more prone to clotting and is associated with increased risk of heart attack and stroke. This is a meaningful finding that warrants attention to reduce inflammation and protect your heart health.
Recommended actions
Adopt an anti-inflammatory diet rich in omega-3 fatty acids from fish, walnuts, and flaxseeds
Engage in regular aerobic exercise like brisk walking, swimming, or cycling for 30 minutes most days
If you smoke, prioritize quitting as smoking significantly elevates fibrinogen levels
Retest in 3-6 months after implementing lifestyle changes to monitor improvement
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