Understanding Lab Tests for Systemic Sclerosis (Scleroderma)
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Systemic Sclerosis, also known as scleroderma, is a chronic autoimmune connective tissue disorder that affects the skin, blood vessels, and internal organs. Due to its complex nature and variable symptoms, specific blood tests are essential for accurate diagnosis and monitoring of this condition.
Top Recommended Test
ANA Screen IFA w/ Ref to Titer and Pattern
This is a primary diagnostic test for systemic sclerosis. The ANA (Antinuclear Antibody) Screen uses immunofluorescence assay to detect autoantibodies commonly found in scleroderma patients. High levels of ANA with specific patterns can assist in confirming the diagnosis and help distinguish systemic sclerosis from other autoimmune conditions.
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The Role of Blood Testing in Systemic Sclerosis Diagnosis
Unlike conditions that can be diagnosed through physical examination alone, systemic sclerosis requires specialized laboratory testing to detect specific autoantibodies and immune system markers. These blood tests help confirm the diagnosis, determine disease subtypes, and assess potential organ involvement.
Other Relevant Tests
Anti-dsDNA (Double-Stranded) Antibiodies, EIA
While not commonly associated with systemic sclerosis, research indicates that anti-dsDNA antibodies may be present in a small percentage of patients with this condition. This test can provide additional immunological information and help healthcare providers develop a complete understanding of the patient's autoimmune profile.
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Understanding Your Test Results
Blood test results for systemic sclerosis should always be interpreted in conjunction with clinical symptoms and physical examination findings. Positive autoantibody tests support the diagnosis, but the specific pattern and titer levels can provide valuable information about disease progression and potential complications.
Important Considerations
The information provided here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider or rheumatologist for proper diagnosis, interpretation of test results, and treatment of systemic sclerosis.
