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Skin cancer is an abnormal growth of skin cells caused by DNA damage from ultraviolet radiation exposure, typically from sun or tanning beds. It is caused by mutations in skin cell DNA that trigger uncontrolled cell division, with basal cell carcinoma, squamous cell carcinoma, and melanoma being the three main types. The Vitamin B3 (Nicotinamide) blood test is the most important test for assessing protective nutritional factors that may reduce skin cancer risk.
Skin cancer is caused by DNA damage to skin cells from ultraviolet (UV) radiation exposure, primarily from sunlight and tanning beds. When UV rays penetrate the skin, they damage the genetic material in skin cells, causing mutations that make cells grow uncontrollably. Other contributing factors include fair skin with less protective melanin, a history of severe sunburns, excessive sun exposure over time, family history of skin cancer, weakened immune system, and exposure to certain chemicals like arsenic. People with many moles or unusual moles are also at higher risk for melanoma, the deadliest form of skin cancer.
The Vitamin B3 (Nicotinamide) test is the most important blood test for assessing protective nutritional factors against skin cancer because it measures nicotinamide levels that have been proven to reduce the development of new skin cancers and precancerous actinic keratoses. While skin cancer diagnosis requires a skin biopsy performed by a dermatologist, the Vitamin B3 test helps evaluate your nutritional defense against skin cancer development. Research shows that adequate nicotinamide levels support DNA repair in sun-damaged skin cells and reduce inflammation that contributes to cancer formation. This test is valuable for people with a history of skin cancer, multiple precancerous lesions, or those at high risk who want to optimize their preventive nutrition strategy.
You should get tested if you have a history of multiple skin cancers or precancerous actinic keratoses, if you have fair skin and significant sun exposure throughout your life, if you are undergoing preventive treatment for skin cancer, or if you want to assess your nutritional protection against skin cancer development. Testing Vitamin B3 levels is particularly important if you have been advised by your dermatologist to take nicotinamide supplements for skin cancer prevention, as it helps ensure you maintain therapeutic levels. You should also consider testing if you have a weakened immune system, a family history of skin cancer, or if you have had organ transplantation, as these conditions increase skin cancer risk significantly.
What this means
Your Nicotinamide level is slightly below the optimal range, which may contribute to fatigue, reduced energy production, and decreased cellular function. While not severely deficient, this lower level suggests your body may not be getting enough Vitamin B3 to support optimal metabolism and energy needs.
Recommended actions
Increase intake of B3-rich foods like chicken, turkey, tuna, salmon, and peanuts
Consider a quality B-complex supplement or standalone niacin supplement after consulting with your healthcare provider
Ensure adequate protein intake as your body can convert tryptophan to B3
Retest in 2-3 months after dietary changes or supplementation to track improvement
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