Understanding Lab Tests for Sjögren Syndrome
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Sjögren Syndrome is an autoimmune disorder that primarily affects the glands responsible for producing tears and saliva, leading to dry eyes and dry mouth. Blood tests play a crucial role in diagnosing this condition by detecting specific antibodies and inflammatory markers that indicate autoimmune activity.
Recommended Test
Anti-Cyclic Citrullinated Peptide 3 (Anti-CCP3) IgG
While not a primary diagnostic marker for Sjögren Syndrome, this test may be valuable in certain cases. Some patients with Sjögren Syndrome may have detectable levels of CCP antibodies, particularly those who also have concurrent Rheumatoid Arthritis. This test can help identify overlap syndromes and guide comprehensive autoimmune assessment.
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The Role of Blood Testing in Sjögren Syndrome Diagnosis
While symptoms like dry eyes and mouth may suggest Sjögren Syndrome, blood tests are essential for confirming the diagnosis. These tests detect autoantibodies that the immune system mistakenly produces against the body's own tissues, which is characteristic of this autoimmune condition.
Understanding Your Test Results
The presence of anti-CCP antibodies in someone with suspected Sjögren Syndrome may indicate an overlap condition or the coexistence of multiple autoimmune disorders. Your healthcare provider will interpret these results alongside other clinical findings and symptoms to determine the most appropriate diagnosis and treatment plan.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
