Sample results
Shellfish allergy is an abnormal immune response to proteins found in marine shellfish such as shrimp, crab, lobster, and clams. It is caused by the immune system producing IgE and IgG4 antibodies that mistakenly identify shellfish proteins as harmful invaders. The Allergy-Shellfish Panel is the most important test for diagnosis because it measures specific antibodies to multiple shellfish types in a single comprehensive panel.
Shellfish allergy is caused by an abnormal immune response to specific proteins found in shellfish such as tropomyosin, which is the primary allergen in crustaceans like shrimp, crab, and lobster. When you eat shellfish, your immune system mistakenly identifies these proteins as dangerous invaders and produces antibodies called immunoglobulin E (IgE) and immunoglobulin G4 (IgG4) to fight them. This immune reaction triggers the release of histamine and other chemicals that cause allergic symptoms ranging from mild skin reactions to life-threatening anaphylaxis.
The Allergy-Shellfish Panel is the most important test for shellfish allergy because it measures specific IgE antibodies to multiple types of shellfish including clams, crab, lobster, and shrimp in one comprehensive analysis. This panel identifies which specific shellfish trigger your immune system and helps determine the severity of your allergic response. For more detailed analysis, the Food Allergen Profile, IgE With Component Reflexes provides advanced testing for scallops and shrimp with component-level precision, while the IgG4 Food Panels (III, IV, and VI) measure IgG4 antibodies that can reveal additional immune responses to shrimp, clams, lobster, and crab proteins.
You should get tested if you experience symptoms like hives, itching, swelling of the lips or face, stomach cramps, vomiting, or difficulty breathing within minutes to hours after eating shellfish. Testing is also important if you have a family history of shellfish allergy, have experienced unexplained anaphylaxis, or need to confirm whether you can safely eat certain types of shellfish while avoiding others. Early testing helps you avoid potentially life-threatening reactions and allows your doctor to create an emergency action plan with epinephrine auto-injectors if needed.
What this means
Your test shows elevated IgE antibodies to shrimp, indicating you are sensitized to this shellfish. This positive result suggests your immune system recognizes shrimp proteins as a threat, which can cause allergic symptoms ranging from mild itching and hives to more serious reactions when you eat shrimp.
Recommended actions
Strictly avoid shrimp and check ingredient labels for hidden sources like seafood stock or flavorings
Inform restaurant staff about your allergy to prevent cross-contamination during food preparation
Consult with an allergist to develop an emergency action plan and discuss whether you need an epinephrine auto-injector
Consider testing other crustaceans separately as cross-reactivity is common but not guaranteed
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Sample results
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