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Severe Hepatitis B infection is a life-threatening viral liver disease that causes significant liver damage and can lead to cirrhosis and liver cancer. It is caused by the Hepatitis B virus (HBV), which actively replicates in liver cells, destroying them and triggering inflammation. The Hepatitis Be Antigen test is the most important test for diagnosis because it measures viral replication activity and indicates infection severity.
Severe Hepatitis B infection is caused by the Hepatitis B virus (HBV), which infects liver cells and replicates rapidly, leading to extensive liver damage. The virus spreads through contact with infected blood, semen, or other body fluids, often through unprotected sex, sharing needles, or from mother to baby during childbirth. When the immune system cannot control the viral replication, the infection becomes severe, causing inflammation, scarring, and potentially life-threatening complications like cirrhosis and liver failure.
The Hepatitis Be Antigen (HBeAg) test is the most important test for Severe Hepatitis B infection because it directly measures active viral replication and indicates how contagious and severe the infection is. High levels of HBeAg mean the virus is multiplying rapidly in your liver, which signals a severe infection that needs immediate treatment to prevent permanent liver damage. This test helps doctors determine treatment urgency and monitor whether antiviral therapy is working to suppress the virus and protect your liver from cirrhosis and cancer.
You should get tested if you experience symptoms like extreme fatigue, jaundice (yellowing of skin and eyes), dark urine, severe abdominal pain, or persistent nausea and vomiting. Testing is also critical if you have been exposed to Hepatitis B through unprotected sex with an infected partner, shared needles, or accidental needle sticks in healthcare settings. Anyone already diagnosed with Hepatitis B who notices worsening symptoms or has risk factors for severe disease should get tested immediately to assess infection severity and prevent life-threatening complications.
What this means
Your HBeAg test came back negative, meaning the Hepatitis B virus is not actively replicating at high levels in your liver. This is a favorable result indicating lower viral activity and reduced infectivity to others. If you have chronic Hepatitis B, this may suggest your infection is in a less active phase.
Recommended actions
Continue regular monitoring of your Hepatitis B status with your doctor
Avoid alcohol completely to protect your liver from further damage
Maintain a healthy diet rich in vegetables, lean proteins, and whole grains
Retest HBeAg and other Hepatitis B markers every 6-12 months as recommended
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