Selective IgG deficiency is a primary immunodeficiency disorder characterized by significantly reduced levels of immunoglobulin G antibodies while other immunoglobulin classes remain normal. It is caused by impaired B-cell production or function that specifically affects IgG antibody synthesis, leading to inadequate immune protection against bacterial and viral infections. The IgG, IgA, Indirect Immunofluorescence test is the most important test for diagnosis because it precisely measures all immunoglobulin classes to confirm low IgG levels.
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Selective IgG deficiency is caused by impaired B-cell function that specifically disrupts the production of immunoglobulin G antibodies. B-cells are specialized white blood cells responsible for creating antibodies, and when they fail to produce adequate IgG, your immune system cannot effectively fight bacterial and viral infections. This deficiency can be inherited genetically or develop due to underlying immune system disorders, and it results in recurrent respiratory tract infections, sinusitis, and other bacterial infections that are difficult to clear.
The IgG, IgA, Indirect Immunofluorescence test is the most important test for Selective IgG Deficiency because it measures all major immunoglobulin classes in your blood, including IgG, IgA, and IgM. This comprehensive panel allows healthcare providers to confirm that your IgG levels are significantly below the normal range (typically 700-1600 mg/dL in adults) while verifying that other antibody types remain normal, which is the defining characteristic of selective IgG deficiency. The test provides precise quantification of antibody levels, enabling your doctor to assess the severity of your immune deficiency and develop an appropriate treatment plan that may include immunoglobulin replacement therapy or prophylactic antibiotics.
You should get tested if you experience recurrent respiratory infections such as pneumonia, bronchitis, or sinus infections that keep coming back despite treatment. Testing is especially important if you have frequent bacterial infections that are difficult to clear, persistent ear infections, or if you need antibiotics more than 3-4 times per year. You should also consider testing if you have a family history of immune deficiencies or if your doctor has mentioned concerns about your immune system function after repeated infections.
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What this means
Your test came back negative, meaning no anti-epithelial cell surface antibodies were detected in your blood. This is the expected and healthy result, suggesting no active autoimmune blistering disease affecting the connections between skin cells.
Recommended actions
Continue monitoring any skin symptoms and report new blistering to your doctor
Maintain good skin care practices and protect skin from excessive friction
If you develop unexplained blisters or sores, consider retesting
Follow up with your dermatologist if symptoms persist despite negative results
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