Understanding Lab Tests for Selective IgG Deficiency
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Selective IgG deficiency is a primary immunodeficiency disorder characterized by significantly reduced levels of immunoglobulin G (IgG) antibodies in the blood. IgG antibodies are crucial components of the immune system that help protect against bacterial and viral infections. This condition can lead to increased susceptibility to recurrent respiratory tract infections and other bacterial infections.
Recommended Test
IgG, IgA, Indirect Immunofluorescence
This comprehensive test measures the levels of different immunoglobulin classes, including IgG and IgA antibodies, in the blood. It is essential for diagnosing selective IgG deficiency by identifying abnormally low IgG levels while confirming that other immunoglobulin classes remain normal. The test helps healthcare providers assess the severity of the immune deficiency and determine appropriate treatment strategies.
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Diagnosing Selective IgG Deficiency
Selective IgG deficiency is diagnosed through specialized blood tests that measure the levels of different immunoglobulin classes in the blood. Since symptoms like recurrent infections can be caused by various conditions, accurate laboratory testing is essential to confirm the diagnosis and determine the severity of the immune deficiency.
Understanding Your Results
Normal IgG levels vary by age, with adult reference ranges typically between 700-1600 mg/dL. In selective IgG deficiency, IgG levels are significantly below the normal range while other immunoglobulins like IgA and IgM remain within normal limits. Your healthcare provider will interpret your results in the context of your clinical symptoms and medical history.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. If you have recurrent infections or suspect an immune deficiency, seek medical evaluation promptly.
