Understanding Lab Tests for Selective IgA deficiency
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Selective IgA deficiency is the most common primary immunodeficiency disorder, characterized by low or absent levels of immunoglobulin A (IgA) antibodies while maintaining normal levels of other immunoglobulins. This condition can increase susceptibility to infections, particularly those affecting mucosal surfaces like the respiratory and digestive tracts.
Top Recommended Test
IgG, IgA, Indirect Immunofluorescence
This is a primary diagnostic test that directly measures IgA levels alongside other immunoglobulins. Low or absent IgA levels in the presence of normal IgG and IgM levels confirms the diagnosis of selective IgA deficiency. This test is essential for identifying patients who may have increased susceptibility to infections.
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Diagnosing Selective IgA Deficiency
Diagnosis of selective IgA deficiency requires specific blood tests that measure immunoglobulin levels. Because this condition can affect the accuracy of certain other tests and increase infection risk, proper diagnosis through laboratory testing is essential for appropriate medical management and monitoring.
Other Relevant Tests
Celiac Disease Comprehensive Panel
This panel is important because individuals with selective IgA deficiency may have false-negative results on standard celiac disease tests that rely on IgA antibodies. This comprehensive panel can provide accurate celiac disease screening even in patients with IgA deficiency, as celiac disease occurs more frequently in those with this immunodeficiency.
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Candida albicans Ab (IgG, IgA, IgM)
This test helps assess immune response to Candida infections by measuring antibody levels across all immunoglobulin classes. Low IgA levels against Candida albicans, combined with normal IgG and IgM responses, can support the diagnosis of selective IgA deficiency and help evaluate susceptibility to mucosal fungal infections.
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Clinical Significance
Selective IgA deficiency can range from asymptomatic to causing recurrent infections, autoimmune disorders, and allergic reactions. Early diagnosis through proper blood testing allows healthcare providers to monitor for complications, adjust vaccination schedules, and provide appropriate treatment for infections when they occur.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
