Understanding Lab Tests for Secondary Hyperaldosteronism
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Secondary hyperaldosteronism is a condition where the adrenal glands produce too much aldosterone hormone due to factors outside the adrenal glands, such as kidney disease or certain blood pressure medications. This hormonal imbalance can lead to high blood pressure, low potassium levels, and fluid retention. Accurate diagnosis requires specialized blood testing to measure hormone levels.
Recommended Test
Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS
This test is crucial for diagnosing secondary hyperaldosteronism by measuring the ratio between aldosterone and plasma renin activity. In secondary hyperaldosteronism, this ratio may be normal or slightly elevated because both aldosterone and renin levels are high, which distinguishes it from primary hyperaldosteronism. The LC/MS/MS method provides highly accurate measurements of these hormones, helping healthcare providers determine if excessive aldosterone secretion is due to elevated plasma renin activity from underlying conditions like kidney disease or renovascular hypertension.
2907 reviews
Diagnosing Secondary Hyperaldosteronism
Unlike primary hyperaldosteronism where the adrenal glands themselves are the problem, secondary hyperaldosteronism occurs when other conditions stimulate excessive aldosterone production. The key to diagnosis lies in measuring both aldosterone and renin levels, as both are typically elevated in this condition. This differs from primary hyperaldosteronism where renin is usually suppressed.
Understanding Your Results
In secondary hyperaldosteronism, both aldosterone and renin levels are typically elevated, resulting in a normal or only slightly elevated ratio. This pattern helps distinguish secondary hyperaldosteronism from primary hyperaldosteronism, where the ratio is significantly elevated due to suppressed renin levels. Your healthcare provider will interpret these results alongside your symptoms and medical history to determine the underlying cause and appropriate treatment.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. Certain medications and dietary factors can affect test results, so follow your healthcare provider's instructions for test preparation.
