Understanding Lab Tests for Scleroderma
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Scleroderma, also known as systemic sclerosis, is a group of rare autoimmune diseases that cause hardening and tightening of the skin and connective tissues. This chronic condition can also affect blood vessels, muscles, and internal organs. While diagnosis involves clinical evaluation, specific blood tests are essential for confirming the autoimmune nature of the disease and supporting the diagnostic process.
Top Recommended Test
ANA Screen IFA w/ Ref to Titer and Pattern
This is a primary screening test for scleroderma, as the condition commonly presents with abnormal antinuclear antibody (ANA) levels. A positive ANA screen with specific titer and pattern information is frequently seen in systemic sclerosis and helps confirm the autoimmune nature of the disease.
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The Role of Blood Testing in Scleroderma Diagnosis
As an autoimmune rheumatic disease, scleroderma triggers the production of specific antibodies that can be detected through blood tests. These autoimmune markers are fundamental for confirming the diagnosis and distinguishing scleroderma from other connective tissue disorders with similar symptoms.
Other Relevant Tests
Mitochondrial Antibody with Reflex to Titer
This test detects mitochondrial antibodies that may be present in some cases of scleroderma. While not always elevated, these antibodies can provide additional diagnostic information in the comprehensive evaluation of this complex autoimmune condition.
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Rheumatoid Factor (RA)
Although primarily associated with rheumatoid arthritis, rheumatoid factor can sometimes be present in scleroderma patients. This test helps evaluate the broader autoimmune profile and can be useful in distinguishing between different autoimmune rheumatic diseases.
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Understanding Your Test Results
Scleroderma diagnosis typically involves a combination of clinical symptoms, physical examination findings, and laboratory results. A positive ANA test is particularly significant, as it's found in the majority of scleroderma patients. The specific pattern and titer of the ANA can provide valuable information about disease subtype and prognosis.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. Early detection and proper medical management are crucial for managing scleroderma and preventing complications.
