Understanding Lab Tests for Rotor Syndrome
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Rotor syndrome is a rare, benign genetic disorder that affects the liver's ability to process bilirubin properly. This autosomal recessive condition results in elevated levels of both conjugated (direct) and unconjugated (indirect) bilirubin in the blood, leading to mild jaundice that typically appears in adulthood.
Recommended Test
Bilirubin, Direct
This test measures conjugated (direct) bilirubin levels in the blood. In Rotor syndrome, both direct and indirect bilirubin concentrations are characteristically elevated, making this test crucial for diagnosing this rare genetic bilirubin disorder and distinguishing it from other causes of jaundice.
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Diagnosing Rotor Syndrome
Since Rotor syndrome presents with jaundice that can be confused with other liver conditions, specific blood tests measuring bilirubin levels are essential for accurate diagnosis. The characteristic pattern of elevated bilirubin fractions helps distinguish this benign condition from more serious liver disorders.
Understanding Your Results
In Rotor syndrome, the direct bilirubin test will typically show elevated levels alongside elevated indirect bilirubin. This specific pattern, combined with the absence of other liver function abnormalities, helps healthcare providers confirm the diagnosis of this benign condition.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
