Rodent allergy is an immune system reaction to proteins found in mouse and rat urine, dander, and saliva. It is caused by the immune system producing IgE antibodies against rodent proteins, particularly those found in urine, which become airborne and trigger respiratory symptoms. The Respiratory Allergy Profile is the most important test for diagnosis because it measures specific IgE antibodies to mouse urine proteins.
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Rodent allergy is caused by proteins found in the urine, dander, and saliva of mice and rats. When rodents urinate or groom themselves, these proteins dry and become airborne as microscopic particles that you can breathe in. Your immune system mistakenly identifies these harmless proteins as dangerous invaders and produces IgE antibodies to fight them, triggering allergic reactions. This allergic response causes the release of histamine and other chemicals that lead to your symptoms.
The Respiratory Allergy Profile is the most important test for rodent allergy because it measures specific IgE antibodies your immune system produces in response to mouse urine proteins. This blood test provides definitive evidence that your symptoms are caused by rodent allergens rather than other respiratory triggers like pollen or dust mites. Regional profiles like the Respiratory Allergy Profile Region XIV for California's central valley or Region XV for southern Idaho and Nevada test for mouse urine proteins alongside other common environmental allergens in your area. Elevated IgE levels to rodent proteins confirm the diagnosis and help you understand exactly what is causing your sneezing, congestion, and breathing difficulties.
You should get tested if you develop sneezing, runny nose, itchy eyes, or asthma symptoms in places where rodents may be present, such as older buildings, laboratories, pet stores, or homes with rodent infestations. Testing is particularly important if your symptoms worsen in certain environments but improve when you leave those areas. You should also get tested if you work in research facilities, animal care settings, or pest control where you have regular exposure to mice or rats, or if you notice your breathing problems are worse at night when rodents are typically more active.
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What this means
Your total IgE level is elevated, which indicates your immune system is actively responding to allergens in your environment. This is common in people with respiratory allergies and suggests you're sensitized to one or more of the allergens tested in this panel. Elevated IgE often correlates with symptoms like sneezing, congestion, and itchy eyes.
Recommended actions
Review your specific allergen results to identify your primary triggers
Implement environmental controls like HEPA filters and allergen-proof bedding
Consider starting antihistamines during peak allergy seasons in the Central Valley
Retest annually or after implementing allergy management strategies to track improvement
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