Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Renal artery stenosis is a narrowing of the arteries that supply blood to one or both kidneys. While this condition is primarily diagnosed through imaging studies, blood testing plays a fundamental role in detecting the hormonal and metabolic changes that occur as a result of reduced kidney blood flow.
This test measures the ratio between aldosterone and plasma renin activity in the blood. When renal artery stenosis reduces blood flow to the kidneys, the kidneys respond by increasing renin production, which can lead to elevated plasma renin activity. This test helps detect these hormonal changes that result from the narrowed kidney arteries.
When blood flow to the kidneys is restricted, the kidneys respond by activating hormonal systems, particularly the renin-angiotensin-aldosterone system. Blood tests are essential for monitoring these hormonal changes, assessing kidney function, and helping healthcare providers understand the severity of the condition and guide treatment decisions.
The aldosterone/plasma renin activity ratio can reveal important information about how your kidneys are responding to reduced blood flow. Abnormal results may indicate that the renin-angiotensin-aldosterone system has been activated due to decreased kidney perfusion, which is consistent with renal artery stenosis.
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. Definitive diagnosis of renal artery stenosis typically requires imaging studies, but blood tests provide valuable insight into the condition's impact on your body's hormonal systems.