Disease relapse after bone marrow transplantation occurs when the original cancer or blood disorder for which the transplant was performed returns. It is caused by the survival and regrowth of malignant recipient cells that were not completely eliminated during pre-transplant conditioning therapy. The FISH X/Y Post Opposite Sex Bone Marrow Transplant test is the most important test for diagnosis because it precisely tracks the ratio of donor to recipient cells in the bloodstream.
90-day money-back guarantee
Lab order in minutes
Save a trip to the doctor
Low prices since 2005
Labs within 2 miles
Disease relapse after bone marrow transplant is caused by the survival and regrowth of malignant recipient cells that were not completely eliminated during the pre-transplant conditioning chemotherapy or radiation therapy. These remaining cancer cells or abnormal blood cells from the original disease can hide in protective areas of the body and later multiply, causing the disease to return. The risk of relapse depends on factors like the type and stage of the original disease, the intensity of the conditioning regimen, and how well the donor immune cells establish themselves in your body.
The FISH X/Y Post Opposite Sex Bone Marrow Transplant test is the most important test for monitoring disease relapse after transplant because it precisely distinguishes between donor and recipient cells by identifying X and Y chromosomes. This test uses fluorescent markers to track the percentage of your original cells versus donor cells in your bloodstream. When the test shows an increasing percentage of recipient cells compared to donor cells, it serves as an early warning sign that your original disease may be returning, allowing your healthcare team to intervene before symptoms appear. This test is specifically designed for patients who received transplants from donors of the opposite sex and provides critical information for ongoing transplant monitoring.
You should get tested if you have received a bone marrow transplant from a donor of the opposite sex and are in your regular follow-up period, typically at scheduled intervals recommended by your transplant team. Most transplant centers recommend testing at 30 days, 100 days, 6 months, and annually after transplant, though your doctor may order more frequent testing if you have concerning symptoms like unexplained fatigue, fever, easy bruising, or abnormal blood counts. Early detection through regular monitoring gives your medical team the best chance to adjust treatment before the disease progresses.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
What this means
Your test shows 78% of your blood cells are from the donor, which indicates good engraftment but is slightly below the optimal range for this stage of recovery. While this is encouraging progress, your transplant team will want to monitor this closely to ensure the percentage continues to increase or stabilize rather than decrease.
Recommended actions
Follow your transplant team's immunosuppression medication schedule precisely
Attend all scheduled follow-up appointments to monitor engraftment trends
Report any new symptoms like fatigue, fever, or unusual bruising immediately
Retest chimerism levels as recommended by your oncologist, typically in 2-4 weeks
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
3303 reviews
Sample results
Your 24/7 Personal Lab Guide
Quick questions:
