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Rabies is a fatal viral infection that attacks the central nervous system and is transmitted through the saliva of infected animals, typically via bites. It is caused by the rabies virus from the Lyssavirus genus, which travels along nerve pathways to the brain. The Rabies Vaccine Response End Point Titer is the most important test for confirming adequate immunity after vaccination.
Rabies is caused by the rabies virus (Lyssavirus genus) that infects the central nervous system. The virus is transmitted through the saliva of infected animals, most commonly dogs, bats, raccoons, skunks, and foxes, typically through bite wounds or scratches that break the skin. Once the virus enters the body, it travels along nerve pathways to the brain and spinal cord, causing severe neurological symptoms that are almost always fatal without prompt treatment.
The Rabies Vaccine Response End Point Titer is the most important test for determining if you have adequate immunity after rabies vaccination. This blood test measures the level of neutralizing antibodies your immune system produced in response to the vaccine, with a titer of 0.5 IU/mL or higher indicating sufficient protection. This test is essential for high-risk individuals like veterinarians, animal handlers, laboratory workers, and travelers to rabies-endemic regions who need to verify their immunity status. If your titer falls below protective levels, you will need a booster shot to maintain adequate protection against this deadly virus.
You should get tested if you work with animals professionally as a veterinarian, animal control officer, or wildlife handler, or if you work in a laboratory that handles rabies virus. Testing is also recommended if you have received pre-exposure rabies vaccination and need to verify your immunity status, if you are planning travel to regions where rabies is common, or if your job requires proof of rabies immunity. People with ongoing exposure risks should have their antibody levels checked every 6 months to 2 years to ensure continuous protection.
What this means
Your rabies antibody titer is below the protective threshold of 0.5 IU/mL recommended by the WHO and CDC. This indicates your antibody levels have declined over time and you may not have adequate protection against rabies exposure. A booster vaccination is recommended to restore protective immunity, especially if you have upcoming travel or ongoing animal exposure.
Recommended actions
Schedule a rabies vaccine booster shot as soon as possible
Retest 2-4 weeks after booster to confirm protective levels are achieved
Avoid high-risk animal contact until immunity is confirmed
Consider more frequent monitoring if you work with animals or travel regularly
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