Understanding Lab Tests for Pulmonary Embolism (PE)
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
A pulmonary embolism (PE) is a serious medical condition where a blood clot blocks one of the pulmonary arteries in the lungs. PE is primarily diagnosed through imaging studies and clinical evaluation. While there isn't a single blood test to diagnose PE itself, laboratory testing plays a fundamental role in assessing clotting risk factors and guiding long-term management.
Recommended Test
Factor V (Leiden) Mutation Analysis
This genetic test identifies the Factor V Leiden mutation, which creates a hypercoagulable state that significantly increases the risk of developing blood clots. Since pulmonary embolism typically results from blood clots that travel from the legs to the lungs, identifying this mutation helps assess an individual's predisposition to clotting disorders and guides prevention and treatment strategies.
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Why Blood Testing is Important for PE
Blood tests are essential for identifying underlying genetic factors that increase the risk of developing blood clots, which can lead to pulmonary embolism. Understanding these risk factors helps healthcare providers determine appropriate prevention strategies and treatment duration for patients who have experienced PE.
Understanding Your Risk
The Factor V Leiden mutation is one of the most common inherited clotting disorders. Individuals with this mutation have an increased tendency to form blood clots, which can travel through the bloodstream and potentially block pulmonary arteries. Testing for this mutation is particularly valuable for patients with a personal or family history of blood clots or PE.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. If you suspect you may have a pulmonary embolism, seek immediate medical attention as this is a medical emergency.
